Evidence map›Paper›PMID 12196408›Full record

ArticleGenetics2002

X chromosome effect on maternal recombination and meiotic drive in the mouse.

Elena de La Casa-Esperón, J Concepción Loredo-Osti, Fernando Pardo-Manuel de Villena, Tammi L Briscoe, Jan Michel Malette, Joe E Vaughan, Kenneth Morgan, Carmen Sapienza

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. A long noncoding RNA influences the choice of the X chromosome to be inactivated.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Multiple loci contribute to genome-wide recombination levels in male mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2010
    Article
  8. Article
  9. Characterization of two Mst1-deficient mouse models.Developmental dynamics : an official publication of the American Association of Anatomists · 2008
    Article
  10. Article
  11. Article
  12. Genetic and parent-of-origin influences on X chromosome choice in Xce heterozygous mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2005
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Elena de La Casa-EsperónFels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
J Concepción Loredo-Osti
Fernando Pardo-Manuel de Villena
Tammi L Briscoe
Jan Michel Malette
Joe E Vaughan
Kenneth Morgan
Carmen Sapienza
Temple University · USMcGill University Health Centre · CAUNC Lineberger Comprehensive Cancer Center

Funding

Genetic and Molecular Analysis of DDK SyndromeR01HD034508 · NICHD · TEMPLE UNIV OF THE COMMONWEALTH · PI SAPIENZA, CARMEN · 1997 to 2009
$2.9M
SHARED RESOURCES FOR CANCER RESEARCHR24CA088261 · NCI · TEMPLE UNIVERSITY · PI REDDY, E PREMKUMAR · 2001 to 2005
$1.3M
Maternal Meiotic Drive of Mouse Chromosome 11R01GM062537 · NIGMS · TEMPLE UNIVERSITY · PI SAPIENZA, CARMEN · 2001 to 2004
$1.2M
NCI NIH HHS 5R24 CA88261NICHD NIH HHS R01HD34508NIGMS NIH HHS R01GM62537
6 · The paper itself

Abstract

We observed that maternal meiotic drive favoring the inheritance of DDK alleles at the Om locus on mouse chromosome 11 was correlated with the X chromosome inactivation phenotype of (C57BL/6-Pgk1(a) x DDK)F(1) mothers. The basis for this unexpected observation appears to lie in the well-documented effect of recombination on meiotic drive that results from nonrandom segregation of chromosomes. Our analysis of genome-wide levels of meiotic recombination in females that vary in their X-inactivation phenotype indicates that an allelic difference at an X-linked locus is responsible for modulating levels of recombination in oocytes.

Indexed as

MeiosisRecombination, GeneticX ChromosomeAnimalsDosage Compensation, GeneticFemaleMiceMice, Inbred C57BLModels, Genetic

Identifiers

PMID12196408
PMCPMC1462220
OpenAlexW2099806749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.