ArticleGenetics2002
Historical intensity of natural selection for resistance to tuberculosis.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Gaucher disease protects against tuberculosis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genetic Resistance toFrontiers in immunology · 2018Review
- A Multistrain Mathematical Model To Investigate the Role of Pyrazinamide in the Emergence of Extensively Drug-Resistant Tuberculosis.Antimicrobial agents and chemotherapy · 2017Article
- Insights into secular trends of respiratory tuberculosis: The 20th century Maltese experience.PloS one · 2017Article
- Rapid mortality transition of Pacific Islands in the 19th century.Epidemiology and infection · 2017Article
- Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies.Seminars in immunopathology · 2016Review
- Co-evolution of Mycobacterium tuberculosis and Homo sapiens.Immunological reviews · 2015Review
- Article
- Non-clinical factors associated with TB: important for DOTS impact evaluation and disease elimination.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2014Article
- Year of birth effects in the historical decline of tuberculosis mortality: a reconsideration.PloS one · 2013Article
- Old and new selective pressures on Mycobacterium tuberculosis.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2012Review
- Host-pathogen coevolution in human tuberculosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Drosophila melanogaster Selection for Survival of Bacillus cereus Infection: Life History Trait Indirect Responses.International journal of evolutionary biology · 2012Article
- Introduction: conceptualizing and partitioning the emergence process of zoonotic viruses from wildlife to humans.Current topics in microbiology and immunology · 2007Review
- An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adults.The Journal of experimental medicine · 2006Article
- Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.PLoS medicine · 2006Article
- Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis.PLoS pathogens · 2005Article
- Differential cytokine genotype frequencies among Canadian Aboriginal and Caucasian populations.Genes and immunity · 2005Article
- Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence.Clinical microbiology reviews · 2003Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Infections have long been thought to exert natural selection on humans. Infectious disease resistance is frequently invoked as a mechanism shaping human genetic diversity, but such hypotheses have rarely been quantitatively evaluated with direct measures of disease-related mortality. Enhancement of genetically determined resistance to tuberculosis by natural selection has been proposed as a factor explaining the decline of tuberculosis in Europe and North America in the period 1830-1950 (before the advent of antimicrobial chemotherapy) and the apparently reduced susceptibility of Europeans and their descendants to tuberculosis infection and/or disease. We used Swedish vital statistics from 1891 to 1900 to estimate that individuals who escaped mortality from pulmonary tuberculosis (PTB) during the European tuberculosis epidemic would have enjoyed a fitness advantage of 7-15% per generation compared to individuals who were susceptible to PTB mortality; individuals with 50% protection would have had a selection coefficient of 4-7%/generation. Selection during the peak of the European TB epidemic could have substantially reduced the frequency of already rare alleles conferring increased susceptibility to PTB mortality, but only if the phenotypic effects of these alleles were very large. However, if resistant alleles were rare at the beginning of this period, 300 years would not have been long enough for such selection to increase their frequency to epidemiologically significant levels. Reductions in the frequency of rare susceptibility alleles could have played at most a small part in the decline of the epidemic in the century preceding 1950. Natural selection by PTB deaths during the European TB epidemic alone cannot account for the presently low level of TB disease observed among Europeans and their descendants just prior to the appearance of antibiotic treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.