ArticleGenetics2002
Does Stellate cause meiotic drive in Drosophila melanogaster?
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Genetic variation in recalcitrant repetitive regions of theGenome research · 2025Article
- Intrinsically weak sex chromosome drive through sequential asymmetric meiosis.Science advances · 2025Article
- A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila.Nature cell biology · 2023Article
- TheCells · 2022Article
- Meiotic drive mechanisms: lessons fromProceedings. Biological sciences · 2019Article
- PIWI-interacting RNAs: small RNAs with big functions.Nature reviews. Genetics · 2019Review
- Review
- Review
- The cellular basis of hybrid dysgenesis and Stellate regulation in Drosophila.Current opinion in genetics & development · 2015Review
- Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring.Genome biology · 2015Article
- Y genetic variation and phenotypic diversity in health and disease.Biology of sex differences · 2015Article
- A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse.PLoS genetics · 2012Article
- Bidirectional transcription of a novel chimeric gene mapping to mouse chromosome Yq.BMC evolutionary biology · 2007Article
- Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline.Nucleic acids research · 2007Article
- Genetic evidence that nonhomologous disjunction and meiotic drive are properties of wild-type Drosophila melanogaster male meiosis.Genetics · 2006Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila melanogaster males deficient for the crystal (cry) locus of the Y chromosome that carry between 15 and 60 copies of the X-linked Stellate (Ste) gene are semisterile, have elevated levels of nondisjunction, produce distorted sperm genotype ratios (meiotic drive), and evince hyperactive transcription of Ste in the testes. Ste seems to be the active element in this system, and it has been proposed that the ancestral Ste gene was "selfish" and increased in frequency because it caused meiotic drive. This hypothetical evolutionary history is based on the idea that Ste overexpression, and not the lack of cry, causes the meiotic drive of cry(-) males. To test whether this is true, we have constructed a Ste-deleted X chromosome and examined the phenotype of Ste(-)/cry(-) males. If hyperactivity of Ste were necessary for the transmission defects seen in cry(-) males, cry(-) males completely deficient for Ste would be normal. Although it is impossible to construct a completely Ste(-) genotype, we find that Ste(-)/cry(-) males have exactly the same phenotype as Ste(+)/cry(-) males. The deletion of all X chromosome Ste copies not only does not eliminate meiotic drive and nondisjunction, but it also does not even reduce them below the levels produced when the X carries 15 copies of Ste.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.