ArticleGenetics2002
Genomic changes in nucleotide and dinucleotide frequencies in Pasteurella multocida cultured under high temperature.
Article in Genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Article
- Genomic Signatures Among Acanthamoeba polyphaga Entoorganisms Unveil Evidence of Coevolution.Journal of molecular evolution · 2019Article
- How do eubacterial organisms manage aggregation-prone proteome?F1000Research · 2014Article
- DAMBE5: a comprehensive software package for data analysis in molecular biology and evolution.Molecular biology and evolution · 2013Article
- Comparative genomic analysis of six bacteria belonging to the genus Novosphingobium: insights into marine adaptation, cell-cell signaling and bioremediation.BMC genomics · 2013Article
- Functional biogeography as evidence of gene transfer in hypersaline microbial communities.PloS one · 2010Article
- Mutational patterns cannot explain genome composition: Are there any neutral sites in the genomes of bacteria?PLoS genetics · 2010Article
- Genomic taxonomy of Vibrios.BMC evolutionary biology · 2009Article
- Classification and regression tree (CART) analyses of genomic signatures reveal sets of tetramers that discriminate temperature optima of archaea and bacteria.Archaea (Vancouver, B.C.) · 2008Article
- Different clustering of genomes across life using the A-T-C-G and degenerate R-Y alphabets: early and late signaling on genome evolution?Journal of molecular evolution · 2007Article
- The reach of the genome signature in prokaryotes.BMC evolutionary biology · 2006Article
- Genetic variation in clones of Pseudomonas pseudoalcaligenes after ten months of selection in different thermal environments in the laboratory.Current microbiology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used 94 RAPD primers of different nucleotide composition to probe the genomic differences between a highly virulent P. multocida strain and an attenuated vaccine strain derived from the virulent strain after culturing the latter under increasing temperature for approximately 14,400 generations. The GC content of the vaccine strain is significantly (P < 0.05) lower than that of the virulent strain, contrary to the popular hypothesis of covariation between the GC content and temperature. The frequencies of AA, TA, and TT dinucleotides were higher, and those of AT, GC, and CG dinucleotides were lower, in the vaccine strain than in the virulent strain. A statistic called genomic RAPD entropy is formulated to measure the randomness of the genome, and the genome of the vaccine strain is more random than that of the virulent strain. These differences between the virulent and vaccine strains are interpreted in terms of mutation and selection under increased culturing temperature. A method for estimating substitution rates is developed in the appendix.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.