ArticleJournal of clinical pathology2002
Silent haemoglobin variants and determination of HbA(1c) with the HPLC Bio-Rad Variant II.
Article in Journal of clinical pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 38 citations in OpenAlex.
- Association between Hemoglobin and Hemoglobin AJournal of clinical medicine · 2018Article
- Heterozygous Hemoglobin Sherwood Forest Causing Polycythemia.Case reports in hematology · 2017Article
- P3 Fraction: Effect on HbA1c Values by HPLC.Journal of clinical and diagnostic research : JCDR · 2016Article
- Raised HIF1α during normoxia in high altitude pulmonary edema susceptible non-mountaineers.Scientific reports · 2016Article
- Assessment of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Retinol-Binding Protein 4 (RBP4) in Type 2 Diabetic Patients with Nephropathy.Biomarker insights · 2016Article
- Hemoglobin variants detected by hemoglobin A1c (HbA1c) analysis and the effects on HbA1c measurements.International journal of diabetes in developing countries · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate the determination of HbA(1c) with an automated high performance liquid chromatography (HPLC) method in patients with clinically silent haemoglobin variants.
methodsHbA(1c) values were determined with the ion exchange HPL Bio-Rad Variant II using the high resolution beta thalassaemia programme in patients with silent haemoglobin variants, namely: Hb Graz, Hb Sherwood Forest, Hb O Padova, and Hb D.
resultsAll of these haemoglobin variants caused additional peaks in the chromatograms. No clinically useful HbA(1c) results were produced for patients with Hb Graz and Hb Sherwood Forest, the results for the patient with Hb D were too low, but the results for patients with Hb O Padova were acceptable.
conclusionsThe development of this automated HPLC method modification with high resolution mode aids the identification of interference caused by the described clinically silent haemoglobin variants in HbA(1c) determination.
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