ReviewEnvironmental health perspectives2002
Environmental factors in medically unexplained symptoms and related syndromes: the evidence and the challenge.
Review in Environmental health perspectives, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Quality of life and capsaicin sensitivity in patients with airway symptoms induced by chemicals and scents: a longitudinal study.Environmental health perspectives · 2007Trial
- Physiologic and symptomatic responses to low-level substances in individuals with and without chemical sensitivities: a randomized controlled blinded pilot booth study.Environmental health perspectives · 2005Trial
- Body, mind, and weather: mechanisms of interaction - a narrative review.Postepy psychiatrii neurologii · 2026Review
- Environmental exposure-related health worries, work ability and health, surveyed by occupational health services.International journal of occupational medicine and environmental health · 2025Article
- Susceptibility to radiation adverse effects in veterans with Gulf War illness and healthy civilians.Scientific reports · 2024Article
- Landfill air and odour emissions from an integrated waste management facility.Journal of environmental health science & engineering · 2019Article
- Sick building syndrome and associated risk factors among the population of Gondar town, northwest Ethiopia.Environmental health and preventive medicine · 2018Article
- Evaluating prevalence and risk factors of building-related symptoms among office workers: Seasonal characteristics of symptoms and psychosocial and physical environmental factors.Environmental health and preventive medicine · 2017Article
- Role of polymorphisms of inducible nitric oxide synthase and endothelial nitric oxide synthase in idiopathic environmental intolerances.Mediators of inflammation · 2015Article
- Multiple chemical sensitivity and the workplace: current position and need for an occupational health surveillance protocol.Oxidative medicine and cellular longevity · 2013Article
- Xenobiotic sensor- and metabolism-related gene variants in environmental sensitivity-related illnesses: a survey on the Italian population.Oxidative medicine and cellular longevity · 2013Article
- The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances.International journal of environmental research and public health · 2011Review
- Sickness response symptoms among healthy volunteers after controlled exposures to diesel exhaust and psychological stress.Environmental health perspectives · 2011Article
- A controlled study of the effect of a mindfulness-based stress reduction technique in women with multiple chemical sensitivity, chronic fatigue syndrome, and fibromyalgia.Journal of multidisciplinary healthcare · 2009Article
- Health care utilisation and attitudes towards health care in subjects reporting environmental annoyance from electricity and chemicals.Journal of environmental and public health · 2009Article
- Measuring health outcomes of a multidisciplinary care approach in individuals with chronic environmental conditions using an abbreviated symptoms questionnaire.Journal of multidisciplinary healthcare · 2008Article
- The treatment of pulmonary diseases and respiratory-related conditions with inhaled (nebulized or aerosolized) glutathione.Evidence-based complementary and alternative medicine : eCAM · 2008Article
- Odor processing in multiple chemical sensitivity.Human brain mapping · 2007Article
- The challenges of exposure assessment in health studies of Gulf War veterans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Article
- Prevention of anaphylactic reactions to anaesthetic drugs.Drug safety · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Symptoms, and especially those without clear underlying medical explanations, account for a large percentage of clinical encounters. Many unexplained symptoms have been organized by patients and practitioners into syndromes such as chronic fatigue syndrome, multiple chemical sensitivity, sick building syndrome, Gulf War syndrome, and the like. All these syndromes are defined solely on the basis of symptoms rather than by medical signs. Some of the above-described conditions overlap strongly with explained conditions such as asthma. The relationship of such symptoms and syndromes to environmental exposure is often sharply debated, as is the distinction between the various syndromes. This leads to problems of what type of research should be conducted and who should conduct it. It is time to develop a comprehensive research agenda to sort out nomenclature, epidemiology, and environmental causation for these conditions, moving toward comprehensive and effective public health and clinical approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.