ReviewEnvironmental health perspectives2002
Hazardous air pollutants and asthma.
Review in Environmental health perspectives, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 215 citations in OpenAlex.
- Ambient air toxics and asthma prevalence among a representative sample of US kindergarten-age children.PloS one · 2013Trial
- Workplace Exposures Vary Across Neighborhoods in the US: Implications on Social Vulnerability and Racial/Ethnic Health Disparities.Journal of racial and ethnic health disparities · 2025Article
- Gene regulation and signaling pathways in immune response to respiratory sensitizers: a database analysis.Frontiers in immunology · 2025Article
- Airway Hyperresponsiveness, Inflammation, and Pulmonary Emphysema in Rodent Models Designed to Mimic Exposure to Fuel Oil-Derived Volatile Organic Compounds Encountered during an Experimental Oil Spill.Environmental health perspectives · 2020Article
- Assessment of carcinogenic and toxic substances inToxicology reports · 2020Article
- Mechanisms of soft and hard electrophile toxicities.Toxicology · 2019Review
- Public Health Agency Responses and Opportunities to Protect Against Health Impacts of Climate Change Among US Populations with Multiple Vulnerabilities.Journal of racial and ethnic health disparities · 2018Article
- Characterization and cancer risk assessment of VOCs in home and school environments in gran La Plata, Argentina.Environmental science and pollution research international · 2018Article
- Exposure and risk analysis to particulate matter, metals, and polycyclic aromatic hydrocarbon at different workplaces in Argentina.Environmental science and pollution research international · 2018Article
- Electronic Cigarettes: Their Constituents and Potential Links to Asthma.Current allergy and asthma reports · 2017Review
- Abdominal adiposity intensifies the negative effects of ambient air pollution on lung function in Korean men.International journal of obesity (2005) · 2017Article
- On the road to recovery: Gasoline content regulations and child health.Journal of health economics · 2017Article
- Parental exposures to occupational asthmagens and risk of autism spectrum disorder in a Danish population-based case-control study.Environmental health : a global access science source · 2017Article
- Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development.Journal of autism and developmental disorders · 2016Article
- Inhalation of the reactive aldehyde acrolein promotes antigen sensitization to ovalbumin and enhances neutrophilic inflammation.Journal of immunotoxicology · 2016Article
- High-Throughput Determination of Mercury in Tobacco and Mainstream Smoke from Little Cigars.Journal of analytical toxicology · 2015Article
- Molecular mechanisms of aldehyde toxicity: a chemical perspective.Chemical research in toxicology · 2014Review
- Climate change. A global threat to cardiopulmonary health.American journal of respiratory and critical care medicine · 2014Review
- A new device for formaldehyde and total aldehydes real-time monitoring.Environmental science and pollution research international · 2014Article
- Ganoderma formosanum polysaccharides attenuate Th2 inflammation and airway hyperresponsiveness in a murine model of allergic asthma.SpringerPlus · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Asthma has a high prevalence in the United States, and persons with asthma may be at added risk from the adverse effects of hazardous air pollutants (HAPs). Complex mixtures (fine particulate matter and tobacco smoke) have been associated with respiratory symptoms and hospital admissions for asthma. The toxic ingredients of these mixtures are HAPs, but whether ambient HAP exposures can induce asthma remains unclear. Certain HAPs are occupational asthmagens, whereas others may act as adjuncts during sensitization. HAPs may exacerbate asthma because, once sensitized, individuals can respond to remarkably low concentrations, and irritants lower the bronchoconstrictive threshold to respiratory antigens. Adverse responses after ambient exposures to complex mixtures often occur at concentrations below those producing effects in controlled human exposures to a single compound. In addition, certain HAPs that have been associated with asthma in occupational settings may interact with criteria pollutants in ambient air to exacerbate asthma. Based on these observations and past experience with 188 HAPs, a list of 19 compounds that could have the highest impact on the induction or exacerbation of asthma was developed. Nine additional compounds were identified that might exacerbate asthma based on their irritancy, respirability, or ability to react with biological macromolecules. Although the ambient levels of these 28 compounds are largely unknown, estimated exposures from emissions inventories and limited air monitoring suggest that aldehydes (especially acrolein and formaldehyde) and metals (especially nickel and chromium compounds) may have possible health risk indices sufficient for additional attention. Recommendations for research are presented regarding exposure monitoring and evaluation of biologic mechanisms controlling how these substances induce and exacerbate asthma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.