ArticleProceedings of the National Academy of Sciences of the United States of America2002
Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 115 citations in OpenAlex.
- IKAROS: from chromatin organization to transcriptional elongation control.Cell death and differentiation · 2025Review
- Fine-Tuning of Cholesterol Homeostasis Controls Erythroid Differentiation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- An early start of Coup-TFII promotes γ-globin gene expression in adult erythroid cells.Haematologica · 2021Article
- Erythropoietin Regulates Transcription and YY1 Dynamics in a Pre-established Chromatin Architecture.iScience · 2020Article
- DNA·RNA triple helix formation can function as aProceedings of the National Academy of Sciences of the United States of America · 2019Article
- GATA1 Activity Governed by Configurations ofFrontiers in oncology · 2016Review
- Dynamic enhancer-gene body contacts during transcription elongation.Genes & development · 2015Article
- NFE2 regulates transcription of multiple enzymes in the heme biosynthesis pathway.Haematologica · 2014Article
- Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points.Experimental hematology · 2014Review
- Transcriptional mechanisms underlying hemoglobin synthesis.Cold Spring Harbor perspectives in medicine · 2013Review
- Evolution of hemoglobin and its genes.Cold Spring Harbor perspectives in medicine · 2012Article
- Enhancer and promoter interactions-long distance calls.Current opinion in genetics & development · 2012Review
- Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation.The Journal of biological chemistry · 2012Article
- Article
- The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes.Nucleic acids research · 2011Article
- Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation.Nucleic acids research · 2011Article
- GATA switches as developmental drivers.The Journal of biological chemistry · 2010Review
- Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation.Blood · 2010Article
- USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus.The Journal of biological chemistry · 2010Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The hematopoietic transcription factor GATA-1 regulates erythropoiesis and beta-globin expression. Although consensus GATA-1 binding sites exist throughout the murine beta-globin locus, we found that GATA-1 discriminates among these sites in vivo. Conditional expression of GATA-1 in GATA-1-null cells recapitulated the occupancy pattern. GATA-1 induced RNA polymerase II (pol II) recruitment to subregions of the locus control region and to the beta-globin promoters. The hematopoietic factor NF-E2 cooperated with GATA-1 to recruit pol II to the promoters. We propose that only when GATA-1 attracts pol II to the locus control region can pol II access the promoter in a NF-E2-dependent manner.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.