Evidence map›Paper›PMID 12193610›Full record

ArticleJournal of bacteriology2002

N4 RNA polymerase II, a heterodimeric RNA polymerase with homology to the single-subunit family of RNA polymerases.

S H Willis, K M Kazmierczak, R H Carter, L B Rothman-Denes

Abstract read
In one paragraph

Article in Journal of bacteriology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. International journal of molecular sciences · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Diversity ofFrontiers in microbiology · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

S H WillisDepartment of Molecular Genetics, The University of Chicago, Chicago, Illinois 60637, USA.
K M Kazmierczak
R H Carter
L B Rothman-Denes

Funding

Molecular And Cellular Biology Training ProgramT32GM007183 · NIGMS · UNIVERSITY OF CHICAGO · PI GLICK, BENJAMIN S, RICE, PHOEBE A · 1985 to 2021
$23.9M
PREDOCTORAL TRAINING IN GENETICS AND REGULATIONT32GM007197 · NIGMS · UNIVERSITY OF CHICAGO · PI ROTHMAN-DENES, LUCIA B. B · 1985 to 2020
$17.0M
Transcribing Activities in N4 Infected E. ColiR01AI012575 · NIAID · UNIVERSITY OF CHICAGO · PI ROTHMAN-DENES, LUCIA B. B · 1985 to 2013
$7.0M
NIAID NIH HHS AI 12575NIAID NIH HHS R01 AI012575NIGMS NIH HHS T32 GM007183NIGMS NIH HHS T32 GM007197NIGMS NIH HHS T32 GM 07183NIGMS NIH HHS T32 GM 07197
6 · The paper itself

Abstract

Bacteriophage N4 middle genes are transcribed by a phage-coded, heterodimeric, rifampin-resistant RNA polymerase, N4 RNA polymerase II (N4 RNAPII). Sequencing and transcriptional analysis revealed that the genes encoding the two subunits comprising N4 RNAPII are translated from a common transcript initiating at the N4 early promoter Pe3. These genes code for proteins of 269 and 404 amino acid residues with sequence similarity to the single-subunit, phage-like RNA polymerases. The genes encoding the N4 RNAPII subunits, as well as a synthetic construct encoding a fusion polypeptide, have been cloned and expressed. Both the individually expressed subunits and the fusion polypeptide reconstitute functional enzymes in vivo and in vitro.

Indexed as

Amino Acid SequenceBacteriophage N4DimerizationDNA-Directed RNA PolymerasesEscherichia coliMolecular Sequence DataRecombinant Fusion ProteinsRNA Polymerase IISequence Analysis, DNASequence Homology, Amino AcidViral ProteinsDNA-Directed RNA PolymerasesRecombinant Fusion ProteinsRNA Polymerase IIViral Proteins

Identifiers

PMID12193610
PMCPMC135322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.