Trial reportArchives of disease in childhood. Fetal and neonatal edition2002
Bone mineralisation in premature infants cannot be predicted from serum alkaline phosphatase or serum phosphate.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Multi-nutrient fortification of human milk for preterm infants.The Cochrane database of systematic reviews · 2020Pooled it
- Supplemented vs. unsupplemented human milk on bone mineralization in very low birth weight preterm infants: a randomized clinical trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Trial
- Biochemical markers for metabolic bone disease in preterm infants: insights from a structured Bone Health Programme in the Middle East.BMJ paediatrics open · 2025Article
- Implementation of Parenteral Nutrition Formulations with Increased Calcium and Phosphate Concentrations and Its Impact on Metabolic Bone Disease in Preterm Infants: A Retrospective Single-Centre Study.Children (Basel, Switzerland) · 2025Article
- Diagnostics of Metabolic Bone Disease in Extremely Preterm Infants-Clinical Applicability of Bone Turnover Biochemical Markers and Quantitative Ultrasound.Children (Basel, Switzerland) · 2024Article
- Early elevated alkaline phosphatase as a surrogate biomarker of ongoing metabolic bone disease of prematurity.European journal of pediatrics · 2023Observational
- Relationship of caffeine regimen with osteopenia of prematurity in preterm neonates: a cohort retrospective study.BMC pediatrics · 2022Article
- Metabolic Bone Disease of Prematurity: Risk Factors and Associated Short-Term Outcomes.Nutrients · 2020Observational
- Unveiling the Metabolic Mystery of Fragility Hip Fracture in Indian Patients: A Histomorphometric and Biochemical Correlation.Indian journal of orthopaedics · 2020Article
- Metabolic Bone Disease in Premature Neonates: An Unmet ChallengeJournal of clinical research in pediatric endocrinology · 2020Review
- Article
- A Combined Ultrasonic Backscatter Parameter for Bone Status Evaluation in Neonates.Computational and mathematical methods in medicine · 2020Article
- Disorders of Calcium and Phosphorus Metabolism and the Proteomics/Metabolomics-Based Research.Frontiers in cell and developmental biology · 2020Review
- Association of Protein and Vitamin D Intake With Biochemical Markers in Premature Osteopenic Infants: A Case-Control Study.Frontiers in pediatrics · 2020Article
- Metabolic Bone Disease of Prematurity: Diagnosis and Management.Frontiers in pediatrics · 2019Review
- Serial serum alkaline phosphatase as an early biomarker for osteopenia of prematurity.Medicine · 2016Observational
- Bone status in preterm infant: influences of different nutritional regimens and possible markers of bone disease.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Article
- Metabolic bone disease in the preterm infant: Current state and future directions.World journal of methodology · 2015Article
- Parathyroid hormone as a marker for metabolic bone disease of prematurity.Journal of perinatology : official journal of the California Perinatal Association · 2014Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe bone mineral content of premature infants at term is lower than in mature infants at the same postconceptional age. Serum alkaline phosphatase and serum phosphate are often used as indicators of bone mineralisation.
objectiveTo analyse the association between bone mineral content and serum alkaline phosphatase and serum phosphate.
methodsSerum alkaline phosphatase and phosphate were measured at weekly intervals during admission in 108 premature infants of gestational age below 32 weeks (mean (SD) gestational age 29 (2) weeks; mean (SD) birth weight 1129 (279) g). Bone mineral content was measured at term (mean gestational age 41 weeks) by dual energy x ray absorptiometry and corrected for body size.
resultsSerum alkaline phosphatase was significantly negatively associated with serum phosphate (p < 0.001). Bone mineral content was not associated with mean serum alkaline phosphatase (p = 0.8), peak serum alkaline phosphatase (p = 0.5), or mean serum phosphate (p = 0.2) at term.
conclusionRoutine measurements of serum alkaline phosphatase and serum phosphate are of no use in predicting bone mineralisation outcome in premature infants.
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Registered trials
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