ArticleMolecular psychiatry2002
A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3.
Article in Molecular psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.American journal of human genetics · 2003Pooled it
- A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.Molecular psychiatry · 2005Trial
- Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families.Molecular psychiatry · 2005Trial
- Article
- Mood, stress and longevity: convergence on ANK3.Molecular psychiatry · 2016Article
- A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis.BioData mining · 2015Article
- Effect of chronic valproic Acid treatment on hepatic gene expression profile in wfs1 knockout mouse.PPAR research · 2014Article
- ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.Chinese medical journal · 2012Article
- Article
- Genome-wide searches for bipolar disorder genes.Current psychiatry reports · 2011Article
- Wfs1 mutation makes mice sensitive to insulin-like effect of acute valproic acid and resistant to streptozocin.Journal of physiology and biochemistry · 2011Article
- Copy number variations of chromosome 16p13.1 region associated with schizophrenia.Molecular psychiatry · 2011Article
- An investigation of candidate regions for association with bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- A genome-wide linkage study of bipolar disorder and co-morbid migraine: replication of migraine linkage on chromosome 4q24, and suggestion of an overlapping susceptibility region for both disorders on chromosome 20p11.Journal of affective disorders · 2010Article
- Article
- Lithium: a key to the genetics of bipolar disorder.Genome medicine · 2009Article
- Candidate region linkage analysis in twins discordant or concordant for depression symptomatology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
- Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic association.Journal of neuroscience research · 2008Article
- The genetics of bipolar disorder: genome 'hot regions,' genes, new potential candidates and future directions.Molecular psychiatry · 2008Review
- Genetics of bipolar disorder.Dialogues in clinical neuroscience · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study reports a genomewide scan using linkage analysis for risk genes involved in bipolar disorder with 613 microsatellite markers including additional testing of promising regions. As previously published significant linkage was obtained at chromosome 12q24.3 with a two-point parametric lod score of 3.42 at D12S1639 including all members in both families (empirical P-value 0.00004, genome-wide P-value 0.0417). The multipoint parametric lod score at D12S1639 was 3.63 (genome-wide P-value 0.0265). At chromosome 1p22-p21 a parametric, affecteds-only two-point lod score of 2.75 at marker D1S216 was found (empirical P-value 0.0002, genome-wide P-value 0.1622). A three-point lod score of 2.98 (genome-wide P-value 0.1022) at D1S216, and a multipoint non-parametric analysis with a maximum NPL-all score of 17.60 (P-value 0.00079) at D1S216 further supported this finding. A number of additional loci on chromosomes 4p16, 6q14-q22, 10q26 and 16p13.3 yielded parametric lod scores around or above 2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.