SynthesisMolecular psychiatry2002
A meta-analysis of the association between DRD4 polymorphism and novelty seeking.
Synthesis in Molecular psychiatry, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Dopaminergic Gene Polymorphisms and Personality Traits in Athletes: A Systematic Review and Exploratory Quantitative Synthesis.International journal of molecular sciences · 2026Pooled it
- The nature of individual differences in inhibited temperament and risk for psychiatric disease: A review and meta-analysis.Progress in neurobiology · 2015Pooled it
- Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis.Molecular psychiatry · 2003Pooled it
- A neurocomputational account of reward and novelty processing and effects of psychostimulants in attention deficit hyperactivity disorder.Brain : a journal of neurology · 2018Trial
- The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants.Development and psychopathology · 2015Trial
- Religion priming differentially increases prosocial behavior among variants of the dopamine D4 receptor (DRD4) gene.Social cognitive and affective neuroscience · 2013Trial
- Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls.Molecular psychiatry · 2005Trial
- The 7-Repeat (7R) Variant of theInternational journal of molecular sciences · 2025Article
- Molecular characterization of chicken DA systems reveals that the avian personality gene,Frontiers in neuroanatomy · 2025Article
- Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance.International journal of molecular sciences · 2024Review
- Anxious-depressive attack and rejection sensitivity-Toward a new approach to treatment-resistant depression.Neuropsychopharmacology reports · 2024Review
- Temporal expectations mediated the repetition effect in a sequence in two ways.Cognitive processing · 2023Article
- Art Value Creation and Destruction.Integrative psychological & behavioral science · 2023Article
- The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen.Scientific reports · 2023Article
- Disordered eating in early childhood: DRD4 and DAT1 gene polymorphisms and quality of mother-child interaction.Eating and weight disorders : EWD · 2022Article
- Klerman's "credo" reconsidered: neo-Kraepelinianism, Spitzer's views, and what we can learn from the past.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022Article
- Analysis of DRD2 Gene Polymorphism in the Context of Personality Traits in a Group of Athletes.Genes · 2021Article
- Association between PolymorphismGenes · 2021Article
- Genetic association with boldness and maternal performance in a free-ranging population of grey seals (Halichoerus grypus).Heredity · 2021Article
- Quantifying Behavioral Sensation Seeking With the Aroma Choice Task.Assessment · 2020Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A meta-analytical review of 20 studies (n = 3907) of the association between DRD4 polymorphism and novelty seeking suggests the following conclusions: (a) on average, there is no association between DRD4 polymorphism and novelty seeking (average d = 0.06 with 95% CI of +/- 0.09), where 13 reports suggest that the presence of longer alleles is associated with higher novelty seeking scores and seven reports suggest the opposite; (b) there is a true heterogeneity among the studies (ie, unknown moderators do exist) but the strength of the association between DRD4 polymorphism and novelty seeking in the presence of any (unknown) moderator is likely to be weak; (c) search for moderators has not yielded any reliable explanation for the variability among studies. We propose that to find such moderators, theory-driven research for potential interaction, coupled with larger sample sizes should be employed. The growing availability of powerful statistical techniques, high-throughput genotyping and large numbers of polymorphic markers such as single nucleotide polymorphisms makes such proposed studies increasingly feasible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.