ArticleNeoplasia (New York, N.Y.)
Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 81 citations in OpenAlex.
- Single-cell western blotting of cytoplasmic cytokeratin 8 proteoforms.The Analyst · 2025Article
- Single-cell western blotting of cytoplasmic cytokeratin 8 proteoforms.bioRxiv : the preprint server for biology · 2025Article
- A quantitative spatial cell-cell colocalizations framework enabling comparisons between in vitro assembloids and pathological specimens.Nature communications · 2025Article
- A study of the proteomic expression in patients with complicated parapneumonic pleural effusion.Archives of medical science : AMS · 2023Article
- Proteomic and ultrastructural analysis of Clara cell and type II alveolar epithelial cell-type lung cancer cells.Translational cancer research · 2020Article
- A Multiplexed Cytokeratin Analysis Using Targeted Mass Spectrometry Reveals Specific Profiles in Cancer-Related Pleural Effusions.Neoplasia (New York, N.Y.) · 2016Article
- [Significance of immunohistochemical indicators in diagnosis and prognosis of squamous cell carcinoma and adenocarcinoma of lung].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2014Review
- Proteomic biomarkers in lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2013Review
- miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Three are better than one: plasminogen receptors as cancer theranostic targets.Experimental hematology & oncology · 2013Article
- Lung cancer proteomics: recent advances in biomarker discovery.International journal of proteomics · 2011Article
- A novel method for sample preparation of fresh lung cancer tissue for proteomics analysis by tumor cell enrichment and removal of blood contaminants.Proteome science · 2010Article
- Biomarkers of lung-related diseases: current knowledge by proteomic approaches.Journal of cellular physiology · 2009Review
- Proteomics analysis of protein expression and specific protein oxidation in human papillomavirus transformed keratinocytes upon UVB irradiation.Journal of cellular and molecular medicine · 2009Article
- Mass spectrometry-based proteomic profiling of lung cancer.Proceedings of the American Thoracic Society · 2009Review
- Application and implementation of selective tissue microdissection and proteomic profiling in neurological disease.Neurosurgery · 2009Review
- Keratin 8 expression in head and neck epithelia.BMC cancer · 2008Article
- Two-dimensional polyacrylamide gel electrophoresis analysis of indomethacin-treated human colon cancer cells.World journal of gastroenterology · 2005Article
- The effects of quercetin on SW480 human colon carcinoma cells: a proteomic study.Nutrition journal · 2005Article
- Protein profiles associated with survival in lung adenocarcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
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Authors and funding
15 authors at 1 institution in 2 countries.
Funding
Abstract
Cytokeratins (CK) are intermediate filaments whose expression is often altered in epithelial cancer. Systematic identification of lung adenocarcinoma proteins using two-dimensional polyacrylamide gel electrophoresis and mass spectrometry has uncovered numerous CK isoforms. In this study, 93 lung adenocarcinomas (64 stage I and 29 stage III) and 10 uninvolved lung samples were quantitatively examined for protein expression. Fourteen of 21 isoforms of CK 7, 8, 18, and 19 occurred at significantly higher levels (P < .05) in tumors compared to uninvolved adjacent tissue. Specific isoforms of the four types of CK identified correlated with either clinical outcome or individual clinical-pathological parameters. All five of the CK7 isoforms associated with patient survival represented cleavage products. Two of five CK7 isoforms (nos. 2165 and 2091), one of eight CK8 isoforms (no. 439), and one of three CK19 isoforms (no. 1955) were associated with survival and significantly correlated to their mRNA levels, suggesting that transcription underlies overexpression of these CK isoforms. Our data indicate substantial heterogeneity among CK in lung adenocarcinomas resulting from posttranslational modifications, some of which correlated with patient survival and other clinical parameters. Therefore, specific isoforms of individual CK may have utility as diagnostic or predictive markers in lung adenocarcinomas.
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