ArticleNeoplasia (New York, N.Y.)
Prostate cancer aggressiveness locus on chromosome 7q32-q33 identified by linkage and allelic imbalance studies.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Podocalyxin in Normal Tissue and Epithelial Cancer.Cancers · 2021Review
- Review
- Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma.Cancers · 2020Review
- The microRNA-183 cluster: the family that plays together stays together.Nucleic acids research · 2015Review
- The complexity of prostate cancer: genomic alterations and heterogeneity.Nature reviews. Urology · 2012Review
- Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families.BMC medical genetics · 2012Article
- Inherited susceptibility for aggressive prostate cancer.Asian journal of andrology · 2012Review
- Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35.The Prostate · 2011Article
- Results from a prostate cancer admixture mapping study in African-American men.Human genetics · 2009Article
- Prostate cancer susceptibility loci: finding the genes.Advances in experimental medicine and biology · 2008Review
- mir-29 regulates Mcl-1 protein expression and apoptosis.Oncogene · 2007Article
- Genome-wide linkage scan of prostate cancer Gleason score and confirmation of chromosome 19q.Human genetics · 2007Article
- Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics.Human genetics · 2006Article
- A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer.Molecular cancer · 2006Article
- Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12.Human genetics · 2006Article
- Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- High-resolution analysis of paraffin-embedded and formalin-fixed prostate tumors using comparative genomic hybridization to genomic microarrays.The American journal of pathology · 2003Article
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8 authors.
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Abstract
The biologic aggressiveness of prostate tumors is an important indicator of prognosis. Chromosome 7q32-q33 was recently reported to show linkage to more aggressive prostate cancer, based on Gleason score, in a large sibling pair study. We report confirmation and narrowing of the linked region using finer-scale genotyping. We also report a high frequency of allelic imbalance (AI) defined within this locus in a series of 48 primary prostate tumors from men unselected for family history or disease status. The highest frequency of AI was observed with adjacent markers D7S2531 (52%) and D7S1804 (36%). These two markers delineated a common region of AI, with 24 tumors exhibiting interstitial AI involving one or both markers. The 1.1-Mb candidate region contains relatively few transcripts. Additionally, we observed positive associations between interstitial AI at D7S1804 and early age at diagnosis (P=.03) as well as a high combined Gleason score and tumor stage (P=.06). Interstitial AI at D7S2531 was associated with a positive family history of prostate cancer (P=.05). These data imply that we have localized a prostate cancer tumor aggressiveness loci to chromosome 7q32-q33 that is involved in familial and nonfamilial forms of prostate cancer.
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