ArticleProceedings of the National Academy of Sciences of the United States of America2002
Functional plasticity of an antigen-specific memory CD4 T cell population.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- T-helper cells flexibility: the possibility of reprogramming T cells fate.Frontiers in immunology · 2023Review
- Measuring the Manipulation of T Helper Immune Responses byInternational journal of molecular sciences · 2022Article
- Increased CD4Clinical epigenetics · 2018Article
- The roles of resident, central and effector memory CD4 T-cells in protective immunity following infection or vaccination.Immunology · 2018Review
- Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease.Nature reviews. Immunology · 2016Review
- IRF3 deficiency impacts granzyme B expression and maintenance of memory T cell function in response to viral infection.Microbes and infection · 2015Article
- Memory CD4 T cells in influenza.Current topics in microbiology and immunology · 2015Review
- Recollective homeostasis and the immune consequences of peritransplant depletional induction therapy.Immunological reviews · 2014Review
- Plasticity within the αβ⁺CD4⁺ T-cell lineage: when, how and what for?Open biology · 2013Review
- A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells.Blood · 2011Article
- Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Homeostatic cytokines orchestrate the segregation of CD4 and CD8 memory T-cell reservoirs in mice.Blood · 2011Article
- Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms.Journal of virology · 2010Article
- Effector T cell plasticity: flexibility in the face of changing circumstances.Nature immunology · 2010Review
- Generation, persistence and plasticity of CD4 T-cell memories.Immunology · 2010Review
- Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challenge.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Lactoferrin as a natural immune modulator.Current pharmaceutical design · 2009Review
- Antigenic experience dictates functional role of glycogen synthase kinase-3 in human CD4+ T cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Heterogeneous memory T cells in antiviral immunity and immunopathology.Viral immunology · 2008Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The protective nature of memory immune responses is attributed largely to terminally differentiated memory T cells that retain memory of the antigen via the antigen receptor and memory of the effector functions that initially cleared the pathogen. It is not known whether a given population of antigen-specific memory T cells is endowed with functional flexibility to provide protective responses against antigens reencountered in different immunological contexts. Here, we examine functional properties of influenza hemagglutinin (HA)-specific memory CD4 T cells recovered from adoptive hosts that received in vitro-activated HA-specific T cell receptor-transgenic CD4 T cells 2 months to 1 year previously. We demonstrate that this HA-specific memory CD4 T cell population bearing a clonal T cell receptor can produce predominantly T helper 1 or T helper 2 effector cytokines depending on the nature of the recall stimulus. Our findings reveal remarkable functional plasticity within an antigen-specific memory T cell population and have direct implications for modulating memory T cell function in vaccine design and treatments for autoimmune diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.