Evidence map›Paper›PMID 12190674›Full record

Trial reportThe British journal of surgery2002

Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis.

A Oláh, T Belágyi, A Issekutz, M E Gamal, S Bengmark

Registry-linked trialOpen access · bronzeAbstract readClinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The British journal of surgery, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00517803 (Micronutrient Supplemented Probiotic Yogurt for HIV/AIDS and Other Immunodeficiencies), which is not on this map. Cited by 129 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 14 pooled it
23.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00517803 nacompletednot on this mapstarted 2007, after this paper: background citation

Micronutrient Supplemented Probiotic Yogurt for HIV/AIDS and Other Immunodeficiencies: A Randomized, Placebo-controlled Trial

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2007 to 2009Enrolled24ConditionsHIV Infections, Cancer, Second PrimaryArmsProbiotic Yogurt B: with various micronutrients, Probiotic Yogurt A: Kaiser micronutrients, Probiotic yogurt C: with basic micronutrients, Probiotic Yogurt D: Placebo -- no added micronutrients
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 14 syntheses or guidelines pooled it, 469 citations in OpenAlex.

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  4. Microbiome changes associated with acute and chronic pancreatitis: A systematic review.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2021
    Pooled it
  5. Guideline
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  7. Enteral nutrition formulations for acute pancreatitis.The Cochrane database of systematic reviews · 2015
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

A OláhDepartment of Surgery, Petz Aladár Teaching Hospital, Györ, Hungary. olah.seb@arrabonet.gyor.hu
T Belágyi
A Issekutz
M E Gamal
S Bengmark
Petz Aladár Megyei Oktató Kórház · HUUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicrobial infection of the pancreatic tissue in patients with severe acute pancreatitis increases the morbidity and mortality rates. Colonization of the lower gastrointestinal tract and oropharynx with Gram-negative, but sometimes also Gram-positive, bacteria precedes contamination of the pancreas. The aim of this study was to determine whether lactic acid bacteria such as Lactobacillus plantarum 299 could prevent colonization of the gut by potential pathogens and thus reduce the endotoxaemia associated with acute pancreatitis.

methodsPatients with acute pancreatitis were randomized into two double-blind groups. The treatment group received a freeze-dried preparation containing live L. plantarum 299 in a dose of 109 organisms, together with a substrate of oat fibre, for 1 week by nasojejunal tube. The control group received a similar preparation but the Lactobacillus was inactivated by heat.

resultsA total of 45 patients completed the study. Twenty-two patients received treatment with live and 23 with heat-killed L. plantarum 299. Infected pancreatic necrosis and abscesses occurred in one of 22 patients in the treatment group, compared with seven of 23 in the control group (P = 0.023). The mean length of stay was 13.7 days in the treatment group versus 21.4 days in the control group (P not significant).

conclusionSupplementary L. plantarum 299 was effective in reducing pancreatic sepsis and the number of surgical interventions.

Indexed as

AntibiosisAcute DiseaseAdultAvenaBacteremiaDietary FiberDouble-Blind MethodEnteral NutritionFemaleHumansLactobacillusLength of StayMaleMiddle AgedMultiple Organ FailureNecrosisDietary Fiber

Identifiers

PMID12190674
OpenAlexW2112230262

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.