ArticleBritish journal of cancer2002
Effect of a tumour-derived lipid-mobilising factor on glucose and lipid metabolism in vivo.
Article in British journal of cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- Review
- Small and Large Intestine (II): Inflammatory Bowel Disease, Short Bowel Syndrome, and Malignant Tumors of the Digestive Tract.Nutrients · 2021Review
- Zinc and the Innovative Zinc-α2-Glycoprotein Adipokine Play an Important Role in Lipid Metabolism: A Critical Review.Nutrients · 2021Review
- Pancreatic cancer cachexia: three dimensions of a complex syndrome.British journal of cancer · 2021Review
- Pancreatic Cancer Cachexia: The Role of Nutritional Interventions.Healthcare (Basel, Switzerland) · 2019Review
- Tumor macroenvironment and metabolism.Seminars in oncology · 2014Review
- Pancreatic cancer cachexia: a review of mechanisms and therapeutics.Frontiers in physiology · 2014Review
- Cancer cachexia prevention via physical exercise: molecular mechanisms.Journal of cachexia, sarcopenia and muscle · 2013Article
- A role of active brown adipose tissue in cancer cachexia?Oncology reviews · 2012Review
- Weight loss precedes cancer-specific symptoms in pancreatic cancer-associated diabetes mellitus.Pancreas · 2011Article
- Article
- Article
- Genotype X diet interactions in mice predisposed to mammary cancer. I. Body weight and fat.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Adipose atrophy in cancer cachexia: morphologic and molecular analysis of adipose tissue in tumour-bearing mice.British journal of cancer · 2006Article
- Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer.Prostate cancer and prostatic diseases · 2006Review
- The role of glucocorticoids in the induction of zinc-alpha2-glycoprotein expression in adipose tissue in cancer cachexia.British journal of cancer · 2005Article
- Energy balance in patients with advanced NSCLC, metastatic melanoma and metastatic breast cancer receiving chemotherapy--a longitudinal study.British journal of cancer · 2005Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment of ex-breeder male NMRI mice with lipid mobilising factor isolated from the urine of cachectic cancer patients, caused a significant increase in glucose oxidation to CO2 compared with control mice receiving phosphate buffered saline. Glucose utilisation by various tissues was determined by the 2-deoxyglucose tracer technique and shown to be elevated in brain, heart, brown adipose tissue and gastrocnemius muscle. The tissue glucose metabolic rate was increased almost three-fold in brain, accounting for the ability of lipid mobilising factor to decrease blood glucose levels. Lipid mobilising factor also increased overall lipid oxidation, as determined by the production of 14CO2 from [14C carboxy] triolein, being 67% greater than phosphate buffered saline controls over a 24 h period. There was a significant increase in [14C] lipid accumulation in plasma, liver and white and brown adipose tissue after administration of lipid mobilising factor. These results suggest that changes in carbohydrate metabolism and loss of adipose tissue, together with an increased whole body fatty acid oxidation in cachectic cancer patients, may arise from tumour production of lipid mobilising factor.
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