ArticleBritish journal of cancer2002
Potential role of endocrine gastrin in the colonic adenoma carcinoma sequence.
Article in British journal of cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Association of proton pump inhibitors with gastric and colorectal cancer risk: A systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
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- Association between the Co-administration of Histamine HJournal of Cancer · 2022Article
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- A retrospective analysis of the role of proton pump inhibitors in colorectal cancer disease survival.Current oncology (Toronto, Ont.) · 2016Article
- Anti-Gastrins Antiserum Combined with Lowered Dosage Cytotoxic Drugs to Inhibit the Growth of Human Gastric Cancer SGC7901 Cells in Nude Mice.Journal of Cancer · 2015Article
- Use of Proton Pump Inhibitor and Risk of Colorectal Cancer: A Meta-analysis of Observational Studies.Korean journal of family medicine · 2012Article
- Blocking gastrin and CCK-B autocrine loop affects cell proliferation and apoptosis in vitro.Molecular and cellular biochemistry · 2010Article
- CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells.International journal of cancer · 2010Article
- Effects of gastrin 17 on beta-catenin/Tcf-4 pathway in Colo320WT colon cancer cells.World journal of gastroenterology · 2006Article
- Correlation between the expressions of gastrin, somatostatin and cyclin and cyclin-depend kinase in colorectal cancer.World journal of gastroenterology · 2005Article
- Immunohistochemical study on gastrointestinal endocrine cells of four reptiles.World journal of gastroenterology · 2005Article
- Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women.Journal of gastroenterology · 2005Article
- Correlation between expression of gastrin, somatostatin and cell apoptosis regulation gene bcl-2/bax in large intestine carcinoma.World journal of gastroenterology · 2005Article
- Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production.British journal of pharmacology · 2005Article
- The Epstein-Barr virus protein BMRF1 activates gastrin transcription.Journal of virology · 2005Article
- Coexpression of cholecystokinin-B/gastrin receptor and gastrin gene in human gastric tissues and gastric cancer cell line.World journal of gastroenterology · 2004Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of hyper-gastrinaemia in the incidence of colonic cancer remains to be clarified. The aim of this study was to determine whether cholecystokinin-2 (CCK-2) receptor expression predicts the sensitivity of human colonic adenomas to the proliferative effects of serum hyper-gastrinaemia. Gene expression of the classical (74 kDa) CCK-2 receptor in human colonic adenoma specimens and cell lines, was quantified by real-time PCR. Western blotting, using a CCK-2 receptor antiserum, confirmed protein expression. A transformed human colonic adenoma was grown in SCID mice, with hyper-gastrinaemia induced by proton pump inhibitors. CCK-2 receptor blockade was achieved by using neutralising antiserum. Both human colonic adenoma cell lines and biopsies expressed CCK-2 receptor mRNA at levels comparable with CCK-2 receptor transfected fibroblasts and oxyntic mucosa. Western blotting confirmed immunoreactive CCK-2 receptor bands localised to 45, 74 and 82.5 kDa. Omeprazole and lansoprazole-induced hyper-gastrinaemia (resulting in serum gastrin levels of 34.0 and 153.0 pM, respectively) significantly increased the weight of the human adenoma grafts (43% (P=0.016) and 70% (P=0.014), respectively). The effect of hypergastrinaemia on tumour growth was reversed by use of antiserum directed against the CCK-2 receptor. Hyper-gastrinaemia may promote proliferation of human colonic adenomas that express CCK-2 receptor isoforms.
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