ArticleBritish journal of cancer2002
Do parents of children with congenital malformations have a higher cancer risk? A nationwide study in Denmark.
Article in British journal of cancer, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Linking databases on perinatal health: a review of the literature and current practices in Europe.European journal of public health · 2016Pooled it
- Leveraging the genetics of human face shape boosts the discovery of orofacial cleft risk loci.medRxiv : the preprint server for health sciences · 2026Article
- Is 7p14.1 an orofacial cleft risk locus? Genome-wide study of copy number variation in multiple populations provides both a replication of previous studies and an alternative explanation.medRxiv : the preprint server for health sciences · 2026Article
- Identification of Novel Risk Variants of Non-Syndromic Cleft Palate by Targeted Gene Panel Sequencing.Journal of clinical medicine · 2023Article
- Consistent downregulation of the cleft lip/palate-associated genesFrontiers in oncology · 2022Article
- Evaluating shared genetic influences on nonsyndromic cleft lip/palate and oropharyngeal neoplasms.Genetic epidemiology · 2020Article
- [Evaluating the effect of WNT pathway genes considering interactions on the risk of non-syndromic oral clefts among Chinese populations].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- Cleft lip and palate: Care configuration, national registration, and research strategies.Journal of the World federation of orthodontists · 2020Article
- Nonsyndromic Oral Cleft in First-Degree Relatives of Patients with Acute Lymphoblastic Leukemia.Dentistry journal · 2020Article
- BRCA1 and BRCA2 gene variants and nonsyndromic cleft lip/palate.Birth defects research · 2018Article
- Risk of Congenital Malformations in Children Born Before Paternal Cancer.JNCI cancer spectrum · 2018Article
- Analysis of Parent-of-Origin Effects on the X Chromosome in Asian and European Orofacial Cleft Triads Identifies Associations withFrontiers in genetics · 2018Article
- Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor-BioMed research international · 2018Article
- Nonsyndromic cleft lip and palate, gastric cancer and tooth agenesis.Medicina oral, patologia oral y cirugia bucal · 2018Observational
- Clinical relevance of breast and gastric cancer-associated polymorphisms as potential susceptibility markers for oral clefts in the Brazilian population.BMC medical genetics · 2017Article
- Maternal cancer and congenital anomalies in children - a Danish nationwide cohort study.PloS one · 2017Article
- Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data.Genomics data · 2016Article
- Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate.PLoS genetics · 2015Article
- Genetics of cleft lip and cleft palate.American journal of medical genetics. Part C, Seminars in medical genetics · 2013Review
- Existing data sources for clinical epidemiology: Danish registries for studies of medical genetic diseases.Clinical epidemiology · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate whether parents of children with congenital malformations more often developed cancer after birth of the child, a population-based case-control study in Denmark was undertaken. By linking the Cancer Registry with the Central Population Registry, we identified 8783 cancer patients having their first child born between 1977 and 1995 before the cancer was diagnosed. Parents of 41 206 firstborn children of a 10% random sample of newborns from the Birth Registry between 1980 and 1995 were identified as controls. We obtained malformation diagnoses of children of cases and controls by linking to the Hospital Discharge Registry. We estimated the association between malformation and cancer by using logistic regression, adjusting for maternal age at birth and sex of child. We found no increased risk of cancer in parents having children with malformations in general, but a higher cancer risk in parents of children born with cleft lip/palate, odds ratio (OR) for all cancer=1.8 (95% confidence interval 1.0-3.2), OR for lymphomas=4.2 (1.3-13.5) and OR for leukaemia=8.1 (2.0-33.7). This association was not restricted to cancer cases diagnosed shortly after birth of the child. Our results suggest a common genetic association between these diseases, but further studies are needed.
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