ReviewProceedings of the National Academy of Sciences of the United States of America2002
Induction and maintenance of nonsymmetrical DNA methylation in Neurospora.
Review in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Symmetric adenine methylation is an essential DNA modification in the early-diverging fungus Rhizopus microsporus.Nature communications · 2025Article
- Sexual stage-specific A-to-I mRNA editing is mediated by tRNA-editing enzymes in fungi.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Histone deacetylation and cytosine methylation compartmentalize heterochromatic regions in the genome organization ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Induction of H3K9me3 and DNA methylation by tethered heterochromatin factors inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- DNA methylation pathways and their crosstalk with histone methylation.Nature reviews. Molecular cell biology · 2015Review
- Translational implications of the β-cell epigenome in diabetes mellitus.Translational research : the journal of laboratory and clinical medicine · 2015Review
- Neurospora crassa, a model system for epigenetics research.Cold Spring Harbor perspectives in biology · 2013Review
- DNA methylation regulates phenotype-dependent transcriptional activity in Candida albicans.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Regulation of secondary metabolism by chromatin structure and epigenetic codes.Fungal genetics and biology : FG & B · 2011Review
- Confining euchromatin/heterochromatin territory: jumonji crosses the line.Genes & development · 2010Review
- pHg/pSILBAγ vector system for efficient gene silencing in homobasidiomycetes: optimization of ihpRNA - triggering in the mycorrhizal fungus Laccaria bicolor.Microbial biotechnology · 2010Article
- The DMM complex prevents spreading of DNA methylation from transposons to nearby genes in Neurospora crassa.Genes & development · 2010Article
- Relics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa.Genome research · 2009Article
- Histone modifications and chromatin dynamics: a focus on filamentous fungi.FEMS microbiology reviews · 2008Review
- Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays.Chemistry & biology · 2008Article
- Epigenetic gene regulation in the bacterial world.Microbiology and molecular biology reviews : MMBR · 2006Article
- Avidin plate assay system for enzymatic characterization of a histone lysine methyltransferase.Analytical biochemistry · 2005Article
- Article
- Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.Microbiology and molecular biology reviews : MMBR · 2004Review
- Synthesis of signals for de novo DNA methylation in Neurospora crassa.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
One can imagine a variety of mechanisms that should result in self-perpetuating biological states. It is generally assumed that cytosine methylation is propagated in eukaryotes by enzymes that specifically methylate hemimethylated symmetrical sites (e.g., (5')CpGGpC(5') or (5')CpNpGGpNpC(5')). Although there is wide support for this model, we and others have found examples of methylation that must be propagated by a different mechanism. Most methylated regions of the Neurospora genome that have been examined are products of repeat-induced point mutation, a premeiotic genome defense system that litters duplicated sequences with C.G to T.A mutations and typically leaves them methylated at remaining cytosines. In general, such relics of repeat-induced point mutation are capable of triggering methylation de novo. Nevertheless, some reflect a mechanism that can propagate heterogeneous methylation at nonsymmetrical sites. We propose that de novo and maintenance methylation are manifestations of a single mechanism in Neurospora, catalyzed by the DIM-2 DNA methyltransferase. The action of DIM-2 is controlled by the DIM-5 histone H3 Lys-9 methyltransferase, which in turn is influenced by other modifications of histone H3. DNA methylation indirectly recruits histone deacetylases, providing the framework of a self-reinforcing system that could result in propagation of DNA methylation and the associated silenced chromatin state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.