ArticleJournal of virology2002
Compartmentalization of surface envelope glycoprotein of human immunodeficiency virus type 1 during acute and chronic infection.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Proliferative memory SAMHD1low CD4+ T cells harbour high levels of HIV-1 with compartmentalized viral populations.PLoS pathogens · 2019Article
- A spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host.PLoS pathogens · 2017Article
- HIV migration between blood plasma and cellular subsets before and after HIV therapy.Journal of medical virology · 2016Article
- Phylogenetics and Phyloanatomy of HIV/SIV Intra-Host Compartments and Reservoirs: The Key Role of the Central Nervous System.Current HIV research · 2016Review
- HIV-1 envelope replication and α4β7 utilization among newly infected subjects and their corresponding heterosexual partners.Retrovirology · 2013Article
- Genital tract sequestration of SIV following acute infection.PLoS pathogens · 2011Article
- Multiple independent lineages of HIV-1 persist in breast milk and plasma.AIDS (London, England) · 2011Article
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- Article
- Evolution and recombination of genes encoding HIV-1 drug resistance and tropism during antiretroviral therapy.Virology · 2010Article
- Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus).Veterinary immunology and immunopathology · 2010Review
- HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sites.HIV/AIDS (Auckland, N.Z.) · 2010Article
- Lack of in vivo compartmentalization among HIV-1 infected naïve and memory CD4+ T cell subsets.Virology · 2009Article
- Genetic characterization of hepatitis B virus in peripheral blood leukocytes: evidence for selection and compartmentalization of viral variants with the immune escape G145R mutation.Journal of virology · 2009Article
- Simian immunodeficiency virus envelope compartmentalizes in brain regions independent of neuropathology.Journal of neurovirology · 2006Article
- Intratypic recombination among lineages of type 1 vaccine-derived poliovirus emerging during chronic infection of an immunodeficient patient.Journal of virology · 2005Article
- Semen-specific genetic characteristics of human immunodeficiency virus type 1 env.Journal of virology · 2005Article
- Human immunodeficiency virus type 1 genomic RNA sequences in the female genital tract and blood: compartmentalization and intrapatient recombination.Journal of virology · 2005Article
- Article
- Compartmentalization of human immunodeficiency virus type 1 between blood monocytes and CD4+ T cells during infection.Journal of virology · 2004Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Human immunodeficiency virus type 1 is characterized by extensive genetic heterogeneity. Having previously demonstrated that, in the peripheral blood, the initial viral population is more homogeneous than at subsequent stages of infection, we have extended our studies to tissue samples, allowing comparisons between viral populations in peripheral blood and tissues during both the acute and chronic stages of infection. We found that homogeneity in gp120 sequences during the acute infection phase is not just restricted to the peripheral blood but also extends to other tissue compartments. However, in chronically infected individuals, heterogeneous and distinct viral populations were found in different compartments. We therefore conclude that the dominant and homogeneous viral population observed during the acute infection phase is likely to infiltrate lymphoid tissues and form the genetic bases for subsequent diversification. It is therefore likely that the compartmentalization of viral sequences observed in chronically infected patients reflects a gradual diversification of a common dominant viral variant rather than the preferential migration of distinct viral populations to different tissue compartments at the beginning of infection.
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