ArticleThe Journal of cell biology2002
REN: a novel, developmentally regulated gene that promotes neural cell differentiation.
Article in The Journal of cell biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Functional analysis of Cullin 3 E3 ligases in tumorigenesis.Biochimica et biophysica acta. Reviews on cancer · 2018Review
- KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling.Oncotarget · 2017Article
- Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells.PloS one · 2017Article
- MiR-210 promotes sensory hair cell formation in the organ of corti.BMC genomics · 2016Article
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- KCTD11 tumor suppressor gene expression is reduced in prostate adenocarcinoma.BioMed research international · 2014Article
- The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs).British journal of cancer · 2013Article
- Novel mutations consolidate KCTD7 as a progressive myoclonus epilepsy gene.Journal of medical genetics · 2012Article
- Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation.The Journal of biological chemistry · 2011Article
- The tumor suppressor gene KCTD11REN is regulated by Sp1 and methylation and its expression is reduced in tumors.Molecular cancer · 2010Article
- Silencing the SPCA1 (secretory pathway Ca2+-ATPase isoform 1) impairs Ca2+ homeostasis in the Golgi and disturbs neural polarity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- SHH pathway and cerebellar development.Cerebellum (London, England) · 2009Review
- Constitutional haploinsufficiency of tumor suppressor genes in mentally retarded patients with microdeletions in 17p13.1.Cytogenetic and genome research · 2009Article
- Suppressors of hedgehog signaling: Linking aberrant development of neural progenitors and tumorigenesis.Molecular neurobiology · 2006Review
- Tissue inhibitor of metalloproteinase-2 (TIMP-2) expression is regulated by multiple neural differentiation signals.Journal of neurochemistry · 2006Article
- Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Differentiation of neuroblastoma cell line N1E-115 involves several signaling cascades.Neurochemical research · 2005Article
- REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expansion and fate choice of pluripotent stem cells along the neuroectodermal lineage is regulated by a number of signals, including EGF, retinoic acid, and NGF, which also control the proliferation and differentiation of central nervous system (CNS) and peripheral nervous system (PNS) neural progenitor cells. We report here the identification of a novel gene, REN, upregulated by neurogenic signals (retinoic acid, EGF, and NGF) in pluripotent embryonal stem (ES) cells and neural progenitor cell lines in association with neurotypic differentiation. Consistent with a role in neural promotion, REN overexpression induced neuronal differentiation as well as growth arrest and p27Kip1 expression in CNS and PNS neural progenitor cell lines, and its inhibition impaired retinoic acid induction of neurogenin-1 and NeuroD expression. REN expression is developmentally regulated, initially detected in the neural fold epithelium of the mouse embryo during gastrulation, and subsequently throughout the ventral neural tube, the outer layer of the ventricular encephalic neuroepithelium and in neural crest derivatives including dorsal root ganglia. We propose that REN represents a novel component of the neurogenic signaling cascade induced by retinoic acid, EGF, and NGF, and is both a marker and a regulator of neuronal differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.