ArticleThe Journal of experimental medicine2002
Blockade of HIV-1 infection of New World monkey cells occurs primarily at the stage of virus entry.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Effects of relocation on immunological and physiological measures in female squirrel monkeys (Saimiri boliviensis boliviensis).PloS one · 2021Article
- Human immunodeficiency virus type-1 Tat protein induces secretory leukocyte protease inhibitor expression in African green monkey but not human cells.Virus genes · 2020Article
- Class C CpG Oligodeoxynucleotide Immunomodulatory Response in Aged Squirrel Monkey (Frontiers in aging neuroscience · 2020Article
- How host genetics dictates successful viral zoonosis.PLoS biology · 2019Article
- Article
- Characterization of two distinct early post-entry blocks to HIV-1 in common marmoset lymphocytes.Scientific reports · 2016Article
- HIV-1 Adapts To Replicate in Cells Expressing Common Marmoset APOBEC3G and BST2.Journal of virology · 2016Article
- Identification of Owl Monkey CD4 Receptors Broadly Compatible with Early-Stage HIV-1 Isolates.Journal of virology · 2015Article
- Macaque-tropic human immunodeficiency virus type 1: breaking out of the host restriction factors.Frontiers in microbiology · 2013Article
- TRIM5α and Species Tropism of HIV/SIV.Frontiers in microbiology · 2012Article
- The inside out of lentiviral vectors.Viruses · 2011Review
- High natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier.Journal of virology · 2010Article
- Article
- A New World primate deficient in tetherin-mediated restriction of human immunodeficiency virus type 1.Journal of virology · 2009Article
- Different subcellular localisations of TRIM22 suggest species-specific function.Immunogenetics · 2009Article
- Mode of transmission affects the sensitivity of human immunodeficiency virus type 1 to restriction by rhesus TRIM5alpha.Journal of virology · 2008Article
- Adaptation of the human immunodeficiency virus type 1 envelope glycoproteins to new world monkey receptors.Journal of virology · 2008Article
- Interaction of moloney murine leukemia virus capsid with Ubc9 and PIASy mediates SUMO-1 addition required early in infection.Journal of virology · 2006Article
- Polymorphism of human and primate RANTES, CX3CR1, CCR2 and CXCR4 genes with regard to HIV/SIV infection.Immunogenetics · 2003Article
- Human and simian immunodeficiency virus capsid proteins are major viral determinants of early, postentry replication blocks in simian cells.Journal of virology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
HIV-1 naturally infects chimpanzees and humans, but does not infect Old World monkeys because of replication blocks that occur after virus entry into the cell. To understand the species-specific restrictions operating on HIV-1 infection, the ability of HIV-1 to infect the cells of New World monkeys was examined. Primary cells derived from common marmosets and squirrel monkeys support every phase of HIV-1 replication with the exception of virus entry. Efficient HIV-1 entry typically requires binding of the viral envelope glycoproteins and host cell receptors, CD4 and either CCR5 or CXCR4 chemokine receptors. HIV-1 did not detectably bind or utilize squirrel monkey CD4 for entry, and marmoset CD4 was also very inefficient compared with human CD4. A marmoset CD4 variant, in which residues 48 and 59 were altered to the amino acids found in human CD4, supported HIV-1 entry efficiently. The CXCR4 molecules of both marmosets and squirrel monkeys supported HIV-1 infection, but the CCR5 proteins of both species were only marginally functional. These results demonstrate that the CD4 and CCR5 proteins of New World monkeys represent the major restriction against HIV-1 replication in these primates. Directed adaptation of the HIV-1 envelope glycoproteins to common marmoset receptors might allow the development of New World monkey models of HIV-1 infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.