ArticleThe Journal of experimental medicine2002
Accumulation of immature Langerhans cells in human lymph nodes draining chronically inflamed skin.
Article in The Journal of experimental medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 264 citations in OpenAlex.
- Pooled it
- Skin Deep: Uncovering the Early Events of Crimean-Congo Hemorrhagic Fever Virus at the Tick-Host-Virus Interface.Viruses · 2026Review
- Dermatopathic Lymphadenopathy withInfection and drug resistance · 2026Article
- Treatment of in vitro generated Langerhans cells with JAK-STAT inhibitor reduces their inflammatory potential.Clinical and experimental medicine · 2023Article
- Expansion of Phenotypically Altered Dendritic Cell Populations in the Small Airways and Alveolar Parenchyma in Patients with Chronic Obstructive Pulmonary Disease.Journal of innate immunity · 2023Article
- Mechanisms of lung damage in tuberculosis: implications for chronic obstructive pulmonary disease.Frontiers in cellular and infection microbiology · 2023Review
- Langerhans Cells-Revising Their Role in Skin Pathologies.Journal of personalized medicine · 2022Review
- A subpopulation of green turtle suprabasal epidermal cells are Langerin+ and migrate under in vitro stimulation of the chemokine CCL21.Veterinary research communications · 2022Article
- Immune System Acts on Orthodontic Tooth Movement: Cellular and Molecular Mechanisms.BioMed research international · 2022Review
- Current Strategies for the Treatment of Hepatocellular Carcinoma by Modulating the Tumor Microenvironment via Nano-Delivery Systems: A Review.International journal of nanomedicine · 2022Review
- Clinical, histopathologic, and immunoarchitectural features of dermatopathic lymphadenopathy: an update.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Loricrin: Past, Present, and Future.International journal of molecular sciences · 2020Review
- In Vitro Induction of T Helper 17 Cells by Synergistic Activation of Human Monocyte-Derived Langerhans Cell-Like Cells with Bacterial Agonists.International journal of molecular sciences · 2019Article
- Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22-Specific Th Cells.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Human dendritic cell subsets: an update.Immunology · 2018Review
- NOD1 modulates IL-10 signalling in human dendritic cells.Scientific reports · 2017Article
- Regulation of Langerhans cell functions in a hypoxic environment.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Molecular Mechanisms of Nickel Allergy.International journal of molecular sciences · 2016Review
- Host immune cellular reactions in corneal neovascularization.International journal of ophthalmology · 2016Review
- Langerhans cell origin and regulation.Current opinion in hematology · 2016Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coordinated migration and maturation of dendritic cells (DCs) such as intraepithelial Langerhans cells (LCs) is considered critical for T cell priming in response to inflammation in the periphery. However, little is known about the role of inflammatory mediators for LC maturation and recruitment to lymph nodes in vivo. Here we show in human dermatopathic lymphadenitis (DL), which features an expanded population of LCs in one draining lymph node associated with inflammatory lesions in its tributary skin area, that the Langerin/CD207(+) LCs constitute a predominant population of immature DCs, which express CD1a, and CD68, but not CD83, CD86, and DC-lysosomal-associated membrane protein (LAMP)/CD208. Using LC-type cells generated in vitro in the presence of transforming growth factor (TGF)-beta1, we further found that tumor necrosis factor (TNF)-alpha, as a prototype proinflammatory factor, and a variety of inflammatory stimuli and bacterial products, increase Langerin expression and Langerin dependent Birbeck granules formation in cell which nevertheless lack costimulatory molecules, DC-LAMP/CD208 and potent T cell stimulatory activity but express CCR7 and respond to the lymph node homing chemokines CCL19 and CCL21. This indicates that LC migration and maturation can be independently regulated events. We suggest that during DL, inflammatory stimuli in the skin increase the migration of LCs to the lymph node but without associated maturation. Immature LCs might regulate immune responses during chronic inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.