ArticleIntegrative physiological and behavioral science : the official journal of the Pavlovian Society
A study of the effects of restraint stress on colitis induced by dextran sulphate sodium in singly housed rats.
Article in Integrative physiological and behavioral science : the official journal of the Pavlovian Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Gastrointestinal neuroendocrine peptides/amines in inflammatory bowel disease.World journal of gastroenterology · 2017Review
- Interaction between diet and gastrointestinal endocrine cells.Biomedical reports · 2016Article
- Restraint stress induces and exacerbates intestinal inflammation in interleukin-10 deficient mice.World journal of gastroenterology · 2015Article
- Dextran sulfate sodium-induced colitis alters stress-associated behaviour and neuropeptide gene expression in the amygdala-hippocampus network of mice.Scientific reports · 2015Article
- Repeated predictable stress causes resilience against colitis-induced behavioral changes in mice.Frontiers in behavioral neuroscience · 2014Article
- Increased wall thickness using ultrasonography is associated with inflammation in an animal model of experimental colitis.Clinical and experimental gastroenterology · 2012Article
- The effect of restraint stress on the normal colon and on intestinal inflammation in a model of experimental colitis.Digestive diseases and sciences · 2008Article
- Effect of live Salmonella Ty21a in dextran sulfate sodium-induced colitis.Drug target insights · 2007Article
- Stress increases susceptibility to oxidative/nitrosative mucosal damage in an experimental model of colitis in rats.Digestive diseases and sciences · 2004Article
- An acute stressor enhances sensitivity to a chemical irritant and increases 51CrEDTA permeability of the colon in adult rats.Integrative physiological and behavioral science : the official journal of the Pavlovian SocietyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe inflammatory bowel diseases (Crohn's disease and ulcerative colitis) are multifactorial diseases. Clinical reports indicate that emotional stress may contribute to the onset, progression and remission of these diseases. Using an experimental animal model of ulcerative colitis, the effect of stress on the development of and recovery from symptoms was studied prospectively. Singly housed rats received 4 percent dextran sulphate sodium orally until fecal blood was detected, indicating the presence of colonic erosions. Tap water was then administered until there were no signs of fecal blood. Two hours of restraint stress were administered daily over four successive days, either prior to or after the induction of colitis. Latencies in days to symptom development and recovery were compared to an unstressed group. Daily measures of fluid-intake, body-weight, and hemoglobulin in feces were made.
resultsRats exposed to restraint stress procedures prior to induction of colitis had shorter latencies to development of symptoms. There was no significant difference in latency to recovery. The amount of fluid-intake did not significantly differ between groups, nor did the groups differ in body-weight.
conclusionThere is an effect of stress on the latency to develop colitis induced by dextran sulphate sodium. This preliminary study suggests that the impact of stress may be one factor underlying the emergence of ulcerative colitis.
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