ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2002
Interaction between muscarinic receptor subtype signal transduction pathways mediating bladder contraction.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- Human Urinary Bladder Strip Relaxation by the β-Adrenoceptor Agonist Isoprenaline: Methodological Considerations and Effects of Gender and Age.Frontiers in pharmacology · 2011Article
- The use of occupation isoboles for analysis of a response mediated by two receptors: M2 and M3 muscarinic receptor subtype-induced mouse stomach contractions.The Journal of pharmacology and experimental therapeutics · 2008Article
- M2 mediated contractions of human bladder from organ donors is associated with an increase in urothelial muscarinic receptors.Neurourology and urodynamics · 2007Article
- In vivo pharmacological resultant analysis reveals noncompetitive interactions between opioid antagonists in the rat tail-withdrawal assay.British journal of pharmacology · 2006Article
- Muscarinic receptor transcript and protein density in hypertrophied and atrophied rat urinary bladder.Neurourology and urodynamics · 2006Article
- Mechanisms mediating cholinergic antral circular smooth muscle contraction in rats.World journal of gastroenterology · 2004Article
- The M2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction.American journal of physiology. Regulatory, integrative and comparative physiology · 2004Article
- Muscarinic receptors: what we know.Current urology reports · 2003Review
- Update on overactive bladder: pharmacologic approaches on the horizon.Current urology reports · 2003Review
- Hypertrophy changes the muscarinic receptor subtype mediating bladder contraction from M3 toward M2.American journal of physiology. Regulatory, integrative and comparative physiology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
M(3) muscarinic receptors mediate cholinergic-induced contraction in most smooth muscles. However, in the denervated rat bladder, M(2) receptors participate in contraction because M(3)-selective antagonists [para-fluoro-hexahydro-sila-diphenidol (p-F-HHSiD) and 4-DAMP] have low affinities. However, the affinity of the M(2)-selective antagonist methoctramine in the denervated bladder is consistent with M(3) receptor mediating contraction. It is possible that two pathways interact to mediate contraction: one mediated by the M(2) receptor and one by the M(3) receptor. To determine whether an interaction exists, the inhibitory potencies of combinations of methoctramine and p-F-HHSiD for reversing cholinergic contractions were measured. In normal bladders, all combinations gave additive effects. In denervated bladders, synergistic effects were seen with the 10:1 and 1:1 (methoctramine:p-F-HHSiD wt/wt) combinations. After application of the sarcoplasmic reticulum ATPase inhibitor thapsigargin to normal tissue, the 10:1 and 1:1 ratios became synergistic, mimicking denervated tissue. Thus in normal bladders both M(2) and M(3) receptors can induce contraction. In the denervated bladder, the M(2) and the M(3) receptors interact in a facilitatory manner to mediate contraction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.