Evidence map›Paper›PMID 12184541›Full record

ArticleDigestive diseases and sciences2002

Comparison of cytotoxin genotypes of Helicobacter pylori in stomach and saliva.

Jie Wang, David S Chi, John J Laffan, Chuanfu Li, Donald A Ferguson, Peter Litchfield, Eapen Thomas

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
  2. Article
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  12. Phenotypic analysis of antibiotic resistance and genotypic study of theAntimicrobial resistance and infection control · 2018
    Article
  13. Gut pathogens · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jie WangDepartment of Intemal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614, USA.
David S Chi
John J Laffan
Chuanfu Li
Donald A Ferguson
Peter Litchfield
Eapen Thomas
East Tennessee State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously reported a high prevalence of H. pylori DNA in saliva. In this study, the cytotoxin genotypes of H. pylori strains from both stomach and saliva were compared in 31 patients with gastritis and peptic ulcer. The cagA, vacA m1, vacA m2, and vacA s1 genotypes were analyzed by PCR. The 417 bp PCR products from three patients were also subjected to DNA sequencing analysis. There was 95% agreement between stomach H. pylori isolates and their corresponding saliva DNA in at least one cytotoxin genotype; 86% agreement with two cytotoxin genotypes; 59% agreement with three cytotoxin genotypes; and 27% agreement with all four cytotoxin genotypes studied. DNA sequencing from three patients showed 78.0%, 64.0%, and 66.9% homology of H. pylori from both sources, respectively. The data suggest that more than one H. pylori strain may exist in the stomach and saliva in the same patient.

Indexed as

CytotoxinsDNA, BacterialGastritisGenotypeHelicobacter InfectionsHelicobacter pyloriHumansPeptic UlcerPolymerase Chain ReactionSalivaStomachCytotoxinsDNA, Bacterial

Identifiers

PMID12184541
OpenAlexW87788839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.