Evidence map›Paper›PMID 12183593›Full record

ArticleInfection and immunity2002

Neutrophil-mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice.

S A Fulton, S M Reba, T D Martin, W H Boom

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
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    Article
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  8. 3D Imaging of the TransparentFrontiers in cellular and infection microbiology · 2020
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  9. The Phagocyte Oxidase Controls Tolerance toJournal of immunology (Baltimore, Md. : 1950) · 2018
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

S A FultonDivision of Infectious Diseases, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106-4984, USA. sxf24@po.cwru.edu
S M Reba
T D Martin
W H Boom
University Hospitals of Cleveland · USCase Western Reserve University · US

Funding

MYCOBACTERIUM TUBERCULOSIS INFECTION IN THE LUNGR01HL055967 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI BOOM, W. HENRY · 1995 to 2010
$4.2M
PULMONARY IMMUNE DEFENCES AGAINST M. BOVIS-BCG INFECTIONK08HL004299 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI FULTON, SCOTT A · 2000 to 2004
$631k
NHLBI NIH HHS HL-55967NHLBI NIH HHS K08 HL004299NHLBI NIH HHS K8HL-04299NHLBI NIH HHS R01 HL055967
6 · The paper itself

Abstract

Although neutrophils have been identified as sources of inflammatory cytokines and chemokines, little is known about their immunologic function during mycobacterial infection in the lungs. In this study, we examined the growth of Mycobacterium bovis BCG in the lungs under experimental conditions that altered neutrophil recruitment to the lungs. Depletion and recruitment of neutrophils was associated with respective increases and decreases in M. bovis BCG growth. Thus, neutrophils may enhance mycobacteriocidal immunity in the lungs.

Indexed as

AnimalsChemokine CXCL2ChemokinesFemaleInterferon-gammaLungMiceMice, Inbred C57BLMycobacterium bovisNeutrophilsT-LymphocytesTuberculosis, PulmonaryChemokine CXCL2ChemokinesCxcl2 protein, mouseInterferon-gamma

Identifiers

PMID12183593
PMCPMC128293
OpenAlexW2124593045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.