ArticleInfection and immunity2002
Cellular immunity, but not gamma interferon, is essential for resolution of Babesia microti infection in BALB/c mice.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Immunity beyond borders: non-lethalFrontiers in immunology · 2026Article
- The protective effects of BMSA1 and BMSA5-1-1 proteins against Babesia microti infection.Parasites, hosts and diseases · 2024Article
- Immune Mediators Important for a Protective Secondary Response toPathogens (Basel, Switzerland) · 2024Article
- The Cross-Species Immunity During AcuteFrontiers in cellular and infection microbiology · 2022Article
- Human Babesiosis in Europe.Pathogens (Basel, Switzerland) · 2021Review
- Molecular Characterization and Immunological Evaluation of TruncatedFrontiers in immunology · 2021Article
- Lessons Learned for Pathogenesis, Immunology, and Disease of Erythrocytic Parasites:Frontiers in cellular and infection microbiology · 2021Review
- Article
- Investigating disease severity in an animal model of concurrent babesiosis and Lyme disease.International journal for parasitology · 2019Review
- Robust adaptive immune response againstBlood advances · 2018Article
- Recombinant IFN-γ from the bank vole Myodes glareolus: a novel tool for research on rodent reservoirs of zoonotic pathogens.Scientific reports · 2018Article
- Elimination ofJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Coinfection by Ixodes Tick-Borne Pathogens: Ecological, Epidemiological, and Clinical Consequences.Trends in parasitology · 2016Review
- Macrophages are the determinant of resistance to and outcome of nonlethal Babesia microti infection in mice.Infection and immunity · 2015Article
- Effect of sex steroids on Babesia microti infection in mice.The American journal of tropical medicine and hygiene · 2013Article
- Macrophages are critical for cross-protective immunity conferred by Babesia microti against Babesia rodhaini infection in mice.Infection and immunity · 2012Article
- Persistent babesiosis in a stem cell transplant recipient.Leukemia research · 2011Article
- Human babesiosis.Infectious disease clinics of North America · 2008Review
- Resolution of chronic hepatitis C following parasitosis.World journal of gastroenterology · 2007Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
A new strain of Babesia microti (KR-1) was isolated from a Connecticut resident with babesiosis by hamster inoculation and adapted to C3H/HeJ and BALB/c mice. To examine the relative importance of humoral and cellular immunity for the control of B. microti infection, we compared the course of disease in wild-type BALB/c mice with that in BALB/c SCID mice, JHD-null (B-cell-deficient) mice, and T-cell receptor alphabeta (TCRbeta(-/-)) or gamma interferon (IFN-gamma) (IFN-gamma(-/-)) knockout mice following inoculation with the KR-1-strain. SCID mice and TCRalphabeta knockouts sustained a severe but nonlethal parasitemia averaging 35 to 45% infected erythrocytes. IFN-gamma-deficient mice developed a less severe parasitemia but were able to clear the infection. In contrast, in six of eight JHD-null mice, the levels of parasitemia were indistinguishable from those in the wild-type animals. These data indicate that cellular immunity is critical for the clearance of B. microti in BALB/c mice but that disease resolution can occur even in the absence of IFN-gamma.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.