Evidence map›Paper›PMID 12183587›Full record

ArticleInfection and immunity2002

Campylobacter jejuni from patients with Guillain-Barré syndrome preferentially expresses a GD(1a)-like epitope.

Irving Nachamkin, Jirong Liu, Ming Li, Huong Ung, Anthony P Moran, Martina M Prendergast, Kazim Sheikh

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 103 citations in OpenAlex.

  1. Review
  2. Article
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  4. Article
  5. Guillain-Barré Syndrome Outbreak in Peru 2019 Associated WithNeurology(R) neuroimmunology & neuroinflammation · 2021
    Article
  6. Article
  7. Review
  8. Review
  9. Binding ofFrontiers in microbiology · 2020
    Article
  10. Article
  11. NontypeablemBio · 2019
    Article
  12. Review
  13. Review
  14. Article
  15. Prevalence of virulence genes in strains of Campylobacter jejuni isolated from human, bovine and broiler.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2013
    Article
  16. Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Irving NachamkinDepartment of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283, USA. nachamki@mail.med.upenn.edu
Jirong Liu
Ming Li
Huong Ung
Anthony P Moran
Martina M Prendergast
Kazim Sheikh
University of Pennsylvania · USOllscoil na Gaillimhe – University of Galway · IEJohns Hopkins Medicine · US

Funding

CHINESE PARALYTIC SYNDROME--MECHANISMS AND RELEVANCER01NS031528 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MC KHANN, GUY MEAD · 1993 to 2001
$1.1M
NINDS NIH HHS NS31528
6 · The paper itself

Abstract

GM(1)- and GD(1a)-like ganglioside mimicry in Campylobacter jejuni lipooligosaccharide (LOS) is considered to be involved in the pathogenesis of Campylobacter-induced Guillain-Barré syndrome (GBS). Compared with gastroenteritis-related isolates, GBS-related C. jejuni isolates were strongly associated with the expression of GD(1a)-like mimicry. The presence of a few genes involved in LOS ganglioside mimicry, cst-II, cgtA, and cgtB, was also associated with GBS-related strains. GD(1a)-like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection.

Indexed as

Antigens, BacterialBase SequenceCampylobacter jejuniDNA, BacterialEpitopesGangliosidesGene ExpressionGenes, BacterialG(M1) GangliosideGuillain-Barre SyndromeHumansLipopolysaccharidesMolecular MimicryRisk FactorsVirulenceAntigens, BacterialDNA, BacterialEpitopesganglioside, GD1aGangliosidesG(M1) Gangliosidelipid-linked oligosaccharidesLipopolysaccharides

Identifiers

PMID12183587
PMCPMC128258
OpenAlexW2139258181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.