Evidence map›Paper›PMID 12183583›Full record

ArticleInfection and immunity2002

A Dirofilaria immitis polyprotein up-regulates nitric oxide production.

Hiroyuki Tezuka, Shinjiro Imai, Setsuko Tsukidate, Koichiro Fujita

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. The roles of NO in microbial symbioses.Cellular microbiology · 2011
    Review
  2. Nitric oxide and respiratory helminthic diseases.Journal of biomedicine & biotechnology · 2010
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hiroyuki TezukaSection of Environmental Parasitology, Department of International Health Development, Division of Public Health, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8519, Japan.
Shinjiro Imai
Setsuko Tsukidate
Koichiro Fujita
Tokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the effect of recombinant Dirofilaria immitis polyprotein (rDiAg) on nitric oxide (NO) production by peritoneal macrophages. rDiAg induced NO production by macrophages from wild-type and lipopolysaccharide-hyporesponsive C3H/HeJ, but not CD40(-/-), mice. These results suggest that CD40 is involved in rDiAg-driven NO production by murine macrophages.

Indexed as

AnimalsAntigens, HelminthBase SequenceCD40 AntigensDirofilaria immitisHelminth ProteinsHost-Parasite InteractionsIn Vitro TechniquesMacrophages, PeritonealMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMice, KnockoutNitric OxideNitric Oxide SynthaseAntigens, HelminthCD40 AntigensHelminth ProteinsNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IINos2 protein, mouseRecombinant ProteinsRNA, Messenger

Identifiers

PMID12183583
PMCPMC128244
OpenAlexW2138806455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.