ArticleInfection and immunity2002
Increased host resistance against Pneumocystis carinii pneumonia in gammadelta T-cell-deficient mice: protective role of gamma interferon and CD8(+) T cells.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- T-cell subsets inClinical & translational immunology · 2025Review
- Immune Response inJournal of fungi (Basel, Switzerland) · 2021Review
- The role of the innate immune system on pulmonary infections.Biological chemistry · 2019Review
- Pulmonary Interleukin-17-Positive Lymphocytes Increase during Pneumocystis murina Infection but Are Not Required for Clearance of Pneumocystis.Infection and immunity · 2017Article
- Associating Changes in the Immune System with Clinical Diseases for Interpretation in Risk Assessment.Current protocols in toxicology · 2016Review
- Treatment with Interleukin-7 Restores Host Defense against Pneumocystis in CD4+ T-Lymphocyte-Depleted Mice.Infection and immunity · 2016Article
- T cell-mediated host immune defenses in the lung.Annual review of immunology · 2013Review
- Experimental Pneumocystis lung infection promotes M2a alveolar macrophage-derived MMP12 production.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Colonization by Pneumocystis jirovecii and its role in disease.Clinical microbiology reviews · 2012Review
- Pneumocystis infection in an immunocompetent host can promote collateral sensitization to respiratory antigens.Infection and immunity · 2011Article
- IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Type-I IFN signaling suppresses an excessive IFN-gamma response and thus prevents lung damage and chronic inflammation during Pneumocystis (PC) clearance in CD4 T cell-competent mice.The American journal of pathology · 2010Article
- Gammadelta T cells and Th17 cytokines in hypersensitivity pneumonitis and lung fibrosis.Translational research : the journal of laboratory and clinical medicine · 2009Article
- IL-17A-expressing T cells are essential for bacterial clearance in a murine model of hypersensitivity pneumonitis.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina.Infection and immunity · 2009Article
- Blood concentrations of the cytokines IL-1beta, IL-6, IL-10, TNF-alpha and IFN-gamma during experimentally induced swine dysentery.Acta veterinaria Scandinavica · 2008Article
- Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice.Journal of leukocyte biology · 2008Article
- Exogenous heat-killed Escherichia coli improves alveolar macrophage activity and reduces Pneumocystis carinii lung burden in infant mice.Infection and immunity · 2007Article
- Regulatory T cells dampen pulmonary inflammation and lung injury in an animal model of pneumocystis pneumonia.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia.Infection and immunity · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although a clear relationship between alphabeta T-cell receptor-positive (alphabeta-TCR(+)) CD4(+) T cells and susceptibility to Pneumocystis carinii infection exists, the role of other T-cell subsets is less clearly defined. Previous studies have shown that gammadelta-TCR(+) T cells infiltrate into the lung during P. carinii pneumonia. Therefore, the present study examined the role of gammadelta-TCR(+) T cells in host defense against P. carinii pneumonia. C57BL/6 (control) and B6.129P2-Tcrd(tm1Mom) (gammadelta-TCR(+) T-cell-deficient) mice were inoculated intratracheally with P. carinii. At specific time points, mice were sacrificed and analyzed for P. carinii burden, T-cell subsets, and cytokine levels in lung tissue. Analysis of P. carinii burden showed a more rapid and complete resolution of infection in gammadelta-TCR(+) T-cell-deficient mice than in C57BL/6 controls. This augmented resolution was associated with elevated gamma interferon (IFN-gamma) levels in bronchoalveolar lavage fluid predominantly produced by CD8(+) T cells, as well as an increased recruitment of CD8(+) T cells in general. In separate experiments, neutralization of IFN-gamma or depletion of CD8(+) T cells early during infection abolished the augmented resolution previously observed in gammadelta-TCR(+) T-cell-deficient mice. These results show that the presence of gammadelta-TCR(+) T cells modulates host susceptibility to P. carinii pneumonia through interactions with pulmonary CD8(+) T cells and tissue production of IFN-gamma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.