ArticleInfection and immunity2002
Analysis of pathogen-host cell interactions in purpura fulminans: expression of capsule, type IV pili, and PorA by Neisseria meningitidis in vivo.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Prospective controlled study of the diagnostic value of skin biopsy in patients with presumed meningococcal disease.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2006Trial
- Bactericidal Antibody Responses to Meningococcal Recombinant Outer Membrane Proteins.Journal of microbiology and biotechnology · 2024Article
- Article
- The Host-Pathogen Interactions and Epicellular Lifestyle ofFrontiers in cellular and infection microbiology · 2022Review
- Article
- Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils.Nature communications · 2021Article
- Molecular interactions between Neisseria meningitidis and its human host.Cellular microbiology · 2019Review
- Deletion of D-Lactate Dehydrogenase A inFrontiers in microbiology · 2019Article
- An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans.PLoS pathogens · 2018Article
- A critical role for ATF2 transcription factor in the regulation of E-selectin expression in response to non-endotoxin components of Neisseria meningitidis.Cellular microbiology · 2016Article
- Pathogenesis of meningococcemia.Cold Spring Harbor perspectives in medicine · 2013Review
- Adhesion of Neisseria meningitidis to dermal vessels leads to local vascular damage and purpura in a humanized mouse model.PLoS pathogens · 2013Article
- Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells.Infection and immunity · 2012Article
- Biofilm formation by the human pathogen Neisseria meningitidis.Medical microbiology and immunology · 2010Review
- Examination of type IV pilus expression and pilus-associated phenotypes in Kingella kingae clinical isolates.Infection and immunity · 2010Article
- Clinical and laboratory evidence for Neisseria meningitidis biofilms.Future microbiology · 2009Review
- The macrophage scavenger receptor A is host-protective in experimental meningococcal septicaemia.PLoS pathogens · 2009Article
- Sensing gram-negative bacterial lipopolysaccharides: a human disease determinant?Infection and immunity · 2008Review
- Combining in situ reverse transcriptase polymerase chain reaction, optical microscopy, and X-ray photoelectron spectroscopy to investigate mineral surface-associated microbial activities.Microbial ecology · 2004Article
- lpt6, a gene required for addition of phosphoethanolamine to inner-core lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae.Journal of bacteriology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pattern of meningococcal surface structure expression in different microenvironments following bloodstream invasion in vivo is not known. We used immunohistochemistry to determine the expression of capsule, type IV pili, and PorA by meningococci residing in the skin lesions of children with purpura fulminans. All the skin biopsy samples showed evidence of thrombosis and, frequently, a perivascular inflammatory cell infiltrate consisting of neutrophils (elastase positive) and monocytes/macrophages (CD68 positive). Modified Gram staining revealed 20 to over 100 gram-negative diplococci in each 4-microm-thick section, usually grouped into microcolonies. Immunoperoxidase staining demonstrated that the invading meningococci expressed PorA, capsule, and type IV pilin. Expression of these antigens was not restricted to any particular environment and was found in association with meningococci located in leukocytes, small blood vessels, and the dermal interstitium. Confocal laser scanning microscopy demonstrated coexpression of pilin and capsule by numerous microcolonies. However, there was some discordance in capsule and pilin expression within the microcolonies, suggesting phase variation. The strategy employed in this study will be helpful in investigating invasive bacterial diseases where antigenic and phase variation has a significant impact on virulence and on vaccine design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.