ArticleInfection and immunity2002
The yeast Candida albicans binds complement regulators factor H and FHL-1.
Article in Infection and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 151 citations in OpenAlex.
- Review
- The grand escape - how pathogens outsmart the human complement system.Immunobiology · 2025Review
- Role of Fungi in Tumorigenesis: Promises and Challenges.Annual review of pathology · 2025Review
- The complement system: A key player in the host response to infections.European journal of immunology · 2024Review
- ControllingInfection and immunity · 2024Review
- Non-Journal of fungi (Basel, Switzerland) · 2022Review
- Influence of Glucose onAntibiotics (Basel, Switzerland) · 2022Article
- Estrogen promotes innate immune evasion of Candida albicans through inactivation of the alternative complement system.Cell reports · 2022Article
- Review
- Candida Pathogenicity and Interplay with the Immune System.Advances in experimental medicine and biology · 2021Article
- Interactions Between PathogenicFrontiers in cellular and infection microbiology · 2021Review
- Innate Immune Pattern Recognition Receptors of Mycobacterium tuberculosis: Nature and Consequences for Pathogenesis of Tuberculosis.Advances in experimental medicine and biology · 2021Article
- Moonlighting Proteins at the Candidal Cell Surface.Microorganisms · 2020Review
- Local Activation of the Alternative Pathway of Complement System in Mycotic Keratitis Patient Tear.Frontiers in cellular and infection microbiology · 2020Article
- Quantification of Factor H Mediated Self vs. Non-self Discrimination by Mathematical Modeling.Frontiers in immunology · 2020Article
- Antibacterial Fusion Proteins EnhanceFrontiers in immunology · 2020Article
- Review
- Mechanisms of PathogenicFrontiers in cellular and infection microbiology · 2020Review
- Article
- Immunopathology of Recurrent Vulvovaginal Infections: New Aspects and Research Directions.Frontiers in immunology · 2019Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human facultative pathogenic yeast Candida albicans causes mucocutaneous infections and is the major cause of opportunistic fungal infections in immunocompromised patients. C. albicans activates both the alternative and classical pathway of the complement system. The aim of this study was to assay whether C. albicans binds human complement regulators in order to control complement activation at its surface. We observed binding of two central complement regulators, factor H and FHL-1, from normal human serum to C. albicans by adsorption assays, immunostaining, and fluorescence-activated cell sorter (FACS) analyses. Specificity of acquisition was further confirmed in direct binding assays with purified proteins. The surface-attached regulators maintained their complement regulatory activities and mediated factor I-dependent cleavage of C3b. Adsorption assays with recombinant deletion mutant proteins were used to identify binding domains. Two binding sites were localized. One binding domain common to both factor H and FHL-1 is located in the N-terminal short consensus repeat domains (SCRs) 6 and 7, and the other one located in C-terminal SCRs 19 and 20 is unique to factor H. These data indicate that by surface acquisition of host complement regulators, the human pathogenic yeast C. albicans is able to regulate alternative complement activation at its surface and to inactivate toxic complement activation products.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.