ArticleBMC anesthesiology2002
PKQuest: volatile solutes - application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics.
Article in BMC anesthesiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Heterogeneity of human adipose blood flow.BMC clinical pharmacology · 2007Trial
- Concentration-dependent blood binding: assessing implications through physiologically based Pharmacokinetic modeling of tacrolimus as a case example.Journal of pharmacokinetics and pharmacodynamics · 2025Article
- PKQuest: PBPK modeling of highly lipid soluble and extracellular solutes.ADMET & DMPK · 2019Article
- PKQuest_Java: free, interactive physiologically based pharmacokinetic software package and tutorial.BMC research notes · 2009Article
- Physiological models of body composition and human obesity.Nutrition & metabolism · 2007Article
- [Pharmacokinetic-pharmacodynamic models for inhaled anaesthetics].Der Anaesthesist · 2007Review
- Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat.BMC clinical pharmacology · 2006Article
- Human physiologically based pharmacokinetic model for propofol.BMC anesthesiology · 2005Article
- Physiologically based pharmacokinetic modeling of arterial - antecubital vein concentration difference.BMC clinical pharmacology · 2004Article
- The pharmacokinetics of the interstitial space in humans.BMC clinical pharmacology · 2003Article
- The use of a physiologically based pharmacokinetic model to evaluate deconvolution measurements of systemic absorption.BMC clinical pharmacology · 2003Article
- PKQuest: capillary permeability limitation and plasma protein binding - application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics.BMC clinical pharmacology · 2002Article
- PKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol.BMC clinical pharmacology · 2002Article
- PKQuest: measurement of intestinal absorption and first pass metabolism - application to human ethanol pharmacokinetics.BMC clinical pharmacology · 2002Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
backgroundThe application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that is required for this analysis. PKQuest is a new generic PBPK that is designed to avoid this problem by using a set of "standard human" default parameters that are applicable to most solutes.
resultsPKQuest is used to model the human pharmacokinetics of the volatile solutes. A "standard human" value for the lipid content of the blood and each organ (klip) was chosen. This set of klip and the oil/water partition coefficient then specifies the organ/blood partition for each organ. Using this approach, the pharmacokinetics of inert volatile solute is completely specified by just 2 parameters: the water/air and oil/water partition coefficients. The model predictions of PKQuest were in good agreement with the experimental data for the inert solutes enflurane and nitrous oxide and the metabolized solutes halothane and toluene.
methodsThe experimental data that was modeled was taken from previous publications.
conclusionsThis approach greatly increases the predictive power of the PBPK. For inert volatile solutes the pharmacokinetics are determined just from the water/air and oil/water partition coefficient. Methoxyflurane cannot be modeled by this PBPK because the arterial and end tidal partial pressures are not equal (as assumed in the PBPK). This inequality results from the "washin-washout" artifact in the large airways that is established for solutes with large water/air partition coefficients.PKQuest and the worked examples are available on the web www.pkquest.com.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.