ArticleBMC clinical pharmacology2002
PKQuest: measurement of intestinal absorption and first pass metabolism - application to human ethanol pharmacokinetics.
Article in BMC clinical pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Sleeve gastrectomy surgery: when 2 alcoholic drinks are converted to 4.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2018Trial
- Breast pumping and lactational state exert differential effects on ethanol pharmacokinetics.Alcohol (Fayetteville, N.Y.) · 2010Trial
- Effects of breast pumping on the pharmacokinetics and pharmacodynamics of ethanol during lactation.Clinical pharmacology and therapeutics · 2008Trial
- Heterogeneity of human adipose blood flow.BMC clinical pharmacology · 2007Trial
- Review
- Integration of a physiologically-based pharmacokinetic model with a whole-body, organ-resolved genome-scale model for characterization of ethanol and acetaldehyde metabolism.PLoS computational biology · 2021Article
- PKQuest: PBPK modeling of highly lipid soluble and extracellular solutes.ADMET & DMPK · 2019Article
- Ethanol pharmacokinetics in neonates and infants.Current therapeutic research, clinical and experimental · 2014Review
- PAVA: physiological and anatomical visual analytics for mapping of tissue-specific concentration and time-course data.Journal of pharmacokinetics and pharmacodynamics · 2010Article
- PKQuest_Java: free, interactive physiologically based pharmacokinetic software package and tutorial.BMC research notes · 2009Article
- Quantity of ethanol absorption after excessive hand disinfection using three commercially available hand rubs is minimal and below toxic levels for humans.BMC infectious diseases · 2007Article
- Lactational state modifies alcohol pharmacokinetics in women.Alcoholism, clinical and experimental research · 2007Article
- Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat.BMC clinical pharmacology · 2006Article
- Human physiologically based pharmacokinetic model for propofol.BMC anesthesiology · 2005Article
- Physiologically based pharmacokinetic modeling of arterial - antecubital vein concentration difference.BMC clinical pharmacology · 2004Article
- The pharmacokinetics of the interstitial space in humans.BMC clinical pharmacology · 2003Article
- The use of a physiologically based pharmacokinetic model to evaluate deconvolution measurements of systemic absorption.BMC clinical pharmacology · 2003Article
- PKQuest: capillary permeability limitation and plasma protein binding - application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics.BMC clinical pharmacology · 2002Article
- PKQuest: volatile solutes - application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics.BMC anesthesiology · 2002Article
- PKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol.BMC clinical pharmacology · 2002Article
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1 author.
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Abstract
backgroundPKQuest, a new physiologically based pharmacokinetic (PBPK) program, is applied to human ethanol data. The classical definition of first pass metabolism (FPM) based on the differences in the area under the curve (AUC) for identical intravenous and oral doses is invalid if the metabolism is non-linear (e.g. ethanol). Uncertainties in the measurement of FPM have led to controversy about the magnitude of gastric alcohol metabolism. PKQuest implements a new, rigorous definition of FPM based on finding the equivalent intravenous input function that would produce a blood time course identical to that observed for the oral intake. This input function equals the peripheral availability (PA) and the FPM is defined by: FPM = Total oral dose - PA. PKQuest also provides a quantitative measurement of the time course of intestinal absorption.
methodsPKQuest was applied to previously published ethanol pharmacokinetic data.
resultsThe rate of ethanol absorption is primarily limited by the rate of gastric emptying. For oral ethanol with a meal: absorption is slow (Tilde; 3 hours) and the fractional PKQuest FPM was 36% (0.15 gm/Kg dose) and 7% (0.3 gm/Kg). In contrast, fasting oral ethanol absorption is fast (Tilde; 50 minutes) and FPM is small.
conclusionsThe standard AUC and one compartment methods significantly overestimate the FPM. Gastric ethanol metabolism is not significant. Ingestion of a coincident meal with the ethanol can reduce the peak blood level by about 4 fold at low doses. PKQuest and all the examples are freely available on the web at www.pkquest.com.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.