ArticleBMC clinical pharmacology2002
PKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol.
Article in BMC clinical pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Heterogeneity of human adipose blood flow.BMC clinical pharmacology · 2007Trial
- Multi-species assessment of propranolol pharmacokinetics via minimal and whole-body PBPK modeling.Frontiers in pharmacology · 2026Article
- Effect of Propranolol on Motor Cortex Excitability in Essential Tremor: An Exploratory Study.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- A Physiologically Based Pharmacokinetic Approach to Recommend an Individual Dose of Tacrolimus in Adult Heart Transplant Recipients.Pharmaceutics · 2023Article
- Development and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients.Drug design, development and therapy · 2021Article
- PKQuest: PBPK modeling of highly lipid soluble and extracellular solutes.ADMET & DMPK · 2019Article
- Determination of the most influential sources of variability in tacrolimus trough blood concentrations in adult liver transplant recipients: a bottom-up approach.The AAPS journal · 2014Observational
- BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems.Journal of pharmacokinetics and pharmacodynamics · 2012Article
- Article
- Use of heart rate monitoring for an individualized and time-variant decompression model.European journal of applied physiology · 2010Article
- PKQuest_Java: free, interactive physiologically based pharmacokinetic software package and tutorial.BMC research notes · 2009Article
- Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat.BMC clinical pharmacology · 2006Article
- Human physiologically based pharmacokinetic model for propofol.BMC anesthesiology · 2005Article
- Physiologically based pharmacokinetic modeling of arterial - antecubital vein concentration difference.BMC clinical pharmacology · 2004Article
- The pharmacokinetics of the interstitial space in humans.BMC clinical pharmacology · 2003Article
- The use of a physiologically based pharmacokinetic model to evaluate deconvolution measurements of systemic absorption.BMC clinical pharmacology · 2003Article
- PKQuest: capillary permeability limitation and plasma protein binding - application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics.BMC clinical pharmacology · 2002Article
- PKQuest: volatile solutes - application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics.BMC anesthesiology · 2002Article
- PKQuest: measurement of intestinal absorption and first pass metabolism - application to human ethanol pharmacokinetics.BMC clinical pharmacology · 2002Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific solutes, required specification of a large number of parameters and have not been designed for general use.
methodsThis new PBPK program (PKQuest) includes a "Standardhuman" and "Standardrat" data set so that the user input is minimized. It has a simple user interface, graphical output and many new features: 1) An option that uses the measured plasma concentrations to solve for the time course of the gastrointestinal, intramuscular, intraperotineal or skin absorption and systemic availability of a drug - for a general non-linear system. 2) Capillary permeability limitation defined in terms of the permeability-surface area products. 4) Saturable plasma and tissue protein binding. 5) A lung model that includes perfusion-ventilation mismatch. 6) A general optimization routine using either a global (simulated annealing) or local (Powell) minimization applicable to all model parameters.
resultsPKQuest was applied to measurements of human propranolol pharmacokinetics and intestinal absorption. A meal has two effects: 1) increases portal blood flow by 50%; and 2) decreases liver metabolism by 20%. There is a significant delay in the oval propranolol absorption in fasting subjects that is absent in fed subjects. The oral absorption of the long acting form of propranolol continues for a period of more than 24 hours.
conclusionsPKQuest provides a new general purpose, easy to use, freely distributed www.pkquest.com and physiologically rigorous PBPK software routine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.