ArticleAmerican journal of human genetics2002
Power calculations for a general class of family-based association tests: dichotomous traits.
Article in American journal of human genetics, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations.PloS one · 2013Pooled it
- Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness.Frontiers in immunology · 2019Trial
- Autism and the serotonin transporter: the long and short of it.Molecular psychiatry · 2005Trial
- ACAT1 is not associated with Alzheimer's disease in two independent family-based samples.Molecular psychiatry · 2005Trial
- Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Article
- A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests.Bioinformatics (Oxford, England) · 2021Article
- Innovative approach to identify multigenomic and environmental interactions associated with birth defects in family-based hybrid designs.Genetic epidemiology · 2021Article
- FamEvent: An R Package for Generating and Modeling Time-to-Event Data in Family Designs.Journal of statistical software · 2021Article
- Causal inference in genetic trio studies.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mutations in sphingolipid metabolism genes are associated with ADHD.Translational psychiatry · 2020Article
- Article
- PolyGEE: a generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies.Biostatistics (Oxford, England) · 2018Article
- Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate.Molecular psychiatry · 2016Article
- FARVATX: Family-Based Rare Variant Association Test for X-Linked Genes.Genetic epidemiology · 2016Article
- A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.American journal of human genetics · 2016Article
- Using Incomplete Trios to Boost Confidence in Family Based Association Studies.Frontiers in genetics · 2016Article
- A re-formulation of generalized linear mixed models to fit family data in genetic association studies.Frontiers in genetics · 2015Article
- Analytic power and sample size calculation for the genotypic transmission/disequilibrium test in case-parent trio studies.Biometrical journal. Biometrische Zeitschrift · 2014Article
- Family-based association analysis of serotonin genes in pathological gambling disorder: evidence of vulnerability risk in the 5HT-2A receptor gene.Journal of molecular neuroscience : MN · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Using large-sample theory, we present a unified approach to power calculations for family-based association tests. Currently available methods for power calculations are restricted to special designs or require approximations or simulations. Our analytical approach to power calculations is broadly applicable in many settings. We discuss power calculations for two scenarios that have high practical relevance and in which power previously could only be assessed by simulation studies or by approximations: (1) studies using both affected and unaffected offspring and (2) studies with missing parental information. When the population prevalence is high, it can be worthwhile to genotype unaffected offspring. For many scenarios, high power can be achieved with reasonable sample sizes, even when no parental information is available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.