ArticleSexually transmitted infections2002
Performance of the rapid plasma reagin and the rapid syphilis screening tests in the diagnosis of syphilis in field conditions in rural Africa.
Article in Sexually transmitted infections, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Facilitators and barriers to point-of-care testing for sexually transmitted infections in low- and middle-income countries: a scoping review.BMC infectious diseases · 2022Article
- Laboratory Evaluation of a Commercially Available Rapid Syphilis Test.Journal of clinical microbiology · 2018Article
- Comparison of RPR and ELISA with TPHA for the Diagnosis of Syphilis: Implication for Updating Syphilis Point-of-Care Tests in Ethiopia.Journal of immunology research · 2018Article
- Syphilis.Nature reviews. Disease primers · 2017Review
- Clinical Evaluation of 2 Point-of-Care Lateral Flow Tests for the Diagnosis of Syphilis.Sexually transmitted diseases · 2016Article
- Field evaluation of a dual rapid diagnostic test for HIV infection and syphilis in Lima, Peru.Sexually transmitted infections · 2016Article
- Field Evaluation of a Dual Rapid Immunodiagnostic Test for HIV and Syphilis Infection in Peru.Sexually transmitted diseases · 2016Article
- Article
- The impact of syphilis screening among female sex workers in China: a modelling study.PloS one · 2013Article
- High prevalence of syphilis among demobilized child soldiers in Eastern Congo: a cross-sectional study.Conflict and health · 2011Article
- A multi-centre evaluation of nine rapid, point-of-care syphilis tests using archived sera.Sexually transmitted infections · 2006Article
- Testing for sexually transmitted infections: a brave new world?Sexually transmitted infections · 2006Article
- Prospective, multi-centre clinic-based evaluation of four rapid diagnostic tests for syphilis.Sexually transmitted infections · 2006Article
- Modelling the cost-effectiveness of introducing rapid syphilis tests into an antenatal syphilis screening programme in Mwanza, Tanzania.Sexually transmitted infections · 2006Article
- Why do we need quality-assured diagnostic tests for sexually transmitted infections?Nature reviews. Microbiology · 2006Review
- Why do we need quality-assured diagnostic tests for sexually transmitted infections?Nature reviews. Microbiology · 2006Review
- Surveillance of HIV and syphilis infections among antenatal clinic attendees in Tanzania-2003/2004.BMC public health · 2006Article
- Neonatal pneumonia in developing countries.Archives of disease in childhood. Fetal and neonatal edition · 2005Review
- Performance of routine syphilis serology in the Ethiopian cohort on HIV/AIDS.Sexually transmitted infections · 2004Article
- Evaluation of SD BIOLINE Syphilis 3.0 for Rapid Diagnosis of Syphilis: Report from a Regional Sexually Transmitted Infection Reference Laboratory in North India.Journal of laboratory physiciansArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the rapid plasma reagin (RPR) test performance in the field and to evaluate a new rapid syphilis test (RST) as a primary screen for syphilis.
methods1325 women of reproductive age from rural communities in the Gambia were tested for syphilis seropositivity using a RPR 18 mm circle card and a RST strip. Within 1 week a repeat RPR and a TPHA test were carried out using standard techniques in the laboratory.
resultsComparing field tests to a diagnosis of "active" syphilis defined as laboratory RPR and TPHA positive, the RPR test was 77.5% sensitive and 94.1% specific; the RST was 75.0% sensitive and 95.2% specific. The RST was easier to use and interpret than the RPR test especially where field conditions were difficult. In this setting with a low prevalence of syphilis in the community (3%), the chance of someone with a positive test being confirmed as having serologically active syphilis was less than 50% for both tests.
conclusionsThe appropriateness of syphilis screening using RPR testing in antenatal clinics and health centres should be questioned if there is a low prevalence in the population, conditions for testing are poor, and resources limited. There is still an urgent need for an appropriate rapid syphilis test for field use.
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