ArticleGenome research2002
Inferring alternative splicing patterns in mouse from a full-length cDNA library and microarray data.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Alternative splicing of TGF-betas and their high-affinity receptors T beta RI, T beta RII and T beta RIII (betaglycan) reveal new variants in human prostatic cells.BMC genomics · 2007Article
- Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56,419 completely sequenced and manually annotated full-length cDNAs.Nucleic acids research · 2006Article
- An expectation-maximization algorithm for probabilistic reconstructions of full-length isoforms from splice graphs.Nucleic acids research · 2006Article
- Detecting tissue-specific regulation of alternative splicing as a qualitative change in microarray data.Nucleic acids research · 2004Article
- CLOE: identification of putative functional relationships among genes by comparison of expression profiles between two species.BMC bioinformatics · 2004Article
- Computational comparative analyses of alternative splicing regulation using full-length cDNA of various eukaryotes.RNA (New York, N.Y.) · 2004Article
- Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.Genome research · 2003Article
- Optimization of oligonucleotide arrays and RNA amplification protocols for analysis of transcript structure and alternative splicing.Genome biology · 2003Article
- Selecting for functional alternative splices in ESTs.Genome research · 2002Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although many studies on alternative splicing of specific genes have been reported in the literature, the general mechanism that regulates alternative splicing has not been clearly understood. In this study, we systematically aligned each pair of the 21,076 cDNA sequences of Mus musculus, searched for putative alternative splicing patterns, and constructed a list of potential alternative splicing sites. Two cDNAs are suspected to be alternatively spliced and originating from a common gene if they share most of their region with a high degree of sequence homology, but parts of the sequences are very distinctive or deleted in either cDNA. The list contains the following information: (1) tissue, (2) developmental stage, (3) sequences around splice sites, (4) the length of each gapped region, and (5) other comments. The list is available at http://www.bioinfo.sfc.keio.ac.jp/intron. Our results have predicted a number of unreported alternatively spliced genes, some of which are expressed only in a specific tissue or at a specific developmental stage.
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