ArticleGenome research2002
Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Investigating Motor Coordination Using BXD Recombinant Inbred Mice to Model the Genetic Underpinnings of Developmental Coordination Disorder.Genes, brain, and behavior · 2025Article
- Chemosensory Alterations and Impact on Quality of Life in Persistent Alcohol Drinkers.Alcohol and alcoholism (Oxford, Oxfordshire) · 2023Article
- Insight into genetic regulation of miRNA in mouse brain.BMC genomics · 2019Article
- Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for High or Low Inflammatory Response.Journal of immunology research · 2019Article
- Cross-Species Integrative Functional Genomics in GeneWeaver Reveals a Role for Pafah1b1 in Altered Response to Alcohol.Frontiers in behavioral neuroscience · 2016Article
- Perceptual and neural responses to sweet taste in humans and rodents.Chemosensory perception · 2015Article
- Null mutation of 5α-reductase type I gene alters ethanol consumption patterns in a sex-dependent manner.Behavior genetics · 2015Article
- Influence of sex on genetic regulation of "drinking in the dark" alcohol consumption.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Article
- Genetics of taste receptors.Current pharmaceutical design · 2014Review
- Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to bitter, sweet, and umami taste stimuli.Journal of neurophysiology · 2012Article
- Operant, oral alcoholic beer self-administration by C57BL/6J mice: effect of BHF177, a positive allosteric modulator of GABA(B) receptors.Psychopharmacology · 2012Article
- Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J×129S1/SvImJ inbred mouse cross.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Differential neural representation of oral ethanol by central taste-sensitive neurons in ethanol-preferring and genetically heterogeneous rats.Journal of neurophysiology · 2011Article
- Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats.Journal of neurophysiology · 2011Article
- Genetics of sweet taste preferences.Flavour and fragrance journal · 2011Article
- The complexity of alcohol drinking: studies in rodent genetic models.Behavior genetics · 2010Review
- T1r3 taste receptor involvement in gustatory neural responses to ethanol and oral ethanol preference.Physiological genomics · 2010Article
- In vitro and in vivo models of acute alcohol exposure.World journal of gastroenterology · 2009Review
- Reduced oral ethanol avoidance in mice lacking transient receptor potential channel vanilloid receptor 1.Behavior genetics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Consumption of ethanol solutions by rodents in two-bottle choice tests is a model to study human alcohol intake. Mice of the C57BL/6ByJ strain have higher ethanol preferences and intakes than do mice of the 129P3/J strain. F2 hybrids between these two strains were phenotyped using two-bottle tests involving a choice between water and either 3% or 10% ethanol. High ethanol preferences and intakes of the B6 mice were inherited as additive or dominant traits in the F2 generation. A genome screen using these F2 mice identified three significant linkages. Two loci, on distal chromosome 4 (Ap3q) and proximal chromosome 7 (Ap7q), strongly affected 10% ethanol intake and weakly affected 3% ethanol intake. A male-specific locus on proximal chromosome 8 (Ap8q) affected 3% ethanol preference, but not indexes of 10% ethanol consumption. In addition, six suggestive linkages (on chromosomes 2, 9, 12, 13, 17, and 18) affecting indexes of 3% and/or 10% ethanol consumption were detected. The loci with significant and suggestive linkages accounted for 35-44% of the genetic variation in ethanol consumption phenotypes. No additive-by-additive epistatic interactions were detected for the primary loci with significant and suggestive linkages. However, there were a few modifiers of the primary linkages and a number of interactions among unlinked loci. This demonstrates a significant role of the genetic background in the variation of ethanol consumption.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.