ArticleGenome research2002
CpG methylation modifies the genetic stability of cloned repeat sequences.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- The Influence of CG sites on dynamic DNA sequence mutagenesis in the genomic evolution of mammalian lifespan.Nucleic acids research · 2025Article
- Genome Analysis of a Variant ofMicroorganisms · 2023Article
- Gene-Environment Interactions in Repeat Expansion Diseases: Mechanisms of Environmentally Induced Repeat Instability.Biomedicines · 2023Review
- Impact ofFrontiers in genetics · 2023Article
- Multiplexed Assembly and Annotation of Synthetic Biology Constructs Using Long-Read Nanopore Sequencing.ACS synthetic biology · 2022Article
- Article
- Variable number tandem repeats - Their emerging role in sickness and health.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Modifiers of CAG/CTG Repeat Instability: Insights from Mammalian Models.Journal of Huntington's disease · 2021Review
- RevisitingFrontiers in microbiology · 2018Article
- Repeat Interruptions Modify Age at Onset in Myotonic Dystrophy Type 1 by StabilizingFrontiers in genetics · 2018Article
- Statistical Enrichment of Epigenetic States Around Triplet Repeats that Can Undergo Expansions.Frontiers in neuroscience · 2016Article
- MBRidge: an accurate and cost-effective method for profiling DNA methylome at single-base resolution.Journal of molecular cell biology · 2015Article
- Article
- Epigenetic mechanisms and genome stability.Clinical epigenetics · 2011Article
- Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissues.Human molecular genetics · 2011Article
- Epigenetic changes and non-coding expanded repeats.Neurobiology of disease · 2010Review
- Instability and chromatin structure of expanded trinucleotide repeats.Trends in genetics : TIG · 2009Review
- CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination.PLoS genetics · 2008Article
- Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.Human molecular genetics · 2008Article
- Repair of DNA double-strand breaks within the (GAA*TTC)n sequence results in frequent deletion of the triplet-repeat sequence.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic stability of tandemly repeated DNAs is affected by repeat sequence, tract length, tract purity, and replication direction. Alterations in DNA methylation status are thought to influence many processes of mutagenesis. By use of bacterial and primate cell systems, we have determined the effect of CpG methylation on the genetic stability of cloned di-, tri-, penta- and minisatellite repeated DNA sequences. Depending on the repeat sequence, methylation can significantly enhance or reduce its genetic stability. This effect was evident when repeat tracts were replicated from either direction. Unexpectedly, methylation of adjacent sequences altered the stability of contiguous repeat sequences void of methylatable sites. Of the seven repeat sequences investigated, methylation stabilized five, destabilized one, and had no effect on another. Thus, although methylation generally stabilized repeat tracts, its influence depended on the sequence of the repeat. The current results lend support to the notion that the biological consequences of CpG methylation may be affected through local alterations of DNA structure as well as through direct protein-DNA interactions. In vivo CpG methylation in bacteria may have technical applications for the isolation and stable propagation of DNA sequences that have been recalcitrant to isolation and/or analyses because of their extreme instability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.