ArticleGenome research2002
B-ZIP proteins encoded by the Drosophila genome: evaluation of potential dimerization partners.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 77 citations in OpenAlex.
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- Reassessing the involvement of the CREB pathway in the circadian clock of Drosophila melanogaster.Npj biological timing and sleep · 2024Article
- Genome-Wide Identification and Expression Profiling of the ABF Transcription Factor Family in Wheat (International journal of molecular sciences · 2024Article
- Double DAP-seq uncovered synergistic DNA binding of interacting bZIP transcription factors.Nature communications · 2023Article
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- Altering the Double-Stranded DNA Specificity of the bZIP Domain of Zta with Site-Directed Mutagenesis at N182.ACS omega · 2022Article
- Genome-Wide Identification of bZIP Transcription Factor Genes and Functional Analyses of Two Members inJournal of fungi (Basel, Switzerland) · 2021Article
- Evidence That Runt Acts as a Counter-Repressor of Groucho DuringG3 (Bethesda, Md.) · 2020Article
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- Coiled-coil motif in LBD16 and LBD18 transcription factors are critical for dimerization and biological function in arabidopsis.Plant signaling & behavior · 2018Article
- A-ZIP53, a dominant negative reveals the molecular mechanism of heterodimerization between bZIP53, bZIP10 and bZIP25 involved in Arabidopsis seed maturation.Scientific reports · 2017Article
- Genome-Wide Identification ofInternational journal of genomics · 2017Article
- Drosophila IRBP bZIP heterodimer binds P-element DNA and affects hybrid dysgenesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Stress-MediatedFrontiers in plant science · 2016Review
- Genome-wide analysis of the basic leucine zipper (bZIP) transcription factor gene family in six legume genomes.BMC genomics · 2015Article
- Methylated Cytosines Mutate to Transcription Factor Binding Sites that Drive Tetrapod Evolution.Genome biology and evolution · 2015Article
- Genome-wide systematic characterization of the bZIP transcriptional factor family in tomato (Solanum lycopersicum L.).BMC genomics · 2015Article
- Article
- Spatio-temporal in vivo recording of dCREB2 dynamics in Drosophila long-term memory processing.Neurobiology of learning and memory · 2015Article
- Basic leucine zipper family in barley: genome-wide characterization of members and expression analysis.Molecular biotechnology · 2015Article
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6 authors at 1 institution in 1 country.
Funding
Abstract
The basic region-leucine zipper (B-ZIP) (bZIP) protein motif dimerizes to bind specific DNA sequences. We have identified 27 B-ZIP proteins in the recently sequenced Drosophila melanogaster genome. The dimerization specificity of these 27 B-ZIP proteins was evaluated using two structural criteria: (1) the presence of attractive or repulsive interhelical g<-->e' electrostatic interactions and (2) the presence of polar or charged amino acids in the 'a' and 'd' positions of the hydrophobic interface. None of the B-ZIP proteins contain only aliphatic amino acids in the'a' and 'd' position. Only six of the Drosophila B-ZIP proteins contain a "canonical" hydrophobic interface like the yeast GCN4, and the mammalian JUN, ATF2, CREB, C/EBP, and PAR leucine zippers, characterized by asparagine in the second 'a' position. Twelve leucine zippers contain polar amino acids in the first, third, and fourth 'a' positions. Circular dichroism spectroscopy, used to monitor thermal denaturations of a heterodimerizing leucine zipper system containing either valine (V) or asparagine (N) in the 'a' position, indicates that the V-N interaction is 2.3 kcal/mole less stable than an N-N interaction and 5.3 kcal/mole less stable than a V-V interaction. Thus, we propose that the presence of polar amino acids in novel positions of the 'a' position of Drosophila B-ZIP proteins has led to leucine zippers that homodimerize rather than heterodimerize.
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