ArticleAnnals of the rheumatic diseases2002
Fcgamma receptor IIa, IIIa, and IIIb polymorphisms in German patients with systemic lupus erythematosus: association with clinical symptoms.
Article in Annals of the rheumatic diseases, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06865274 (Multicenter Prospective Interventional Study to Evaluate the Frequency of FCGR3A Gene Polymorphisms in Patients With Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody Disease, and Multiple Sclerosis.), which is not on this map. Cited by 22 papers, 4 of them syntheses that pooled it.
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Multicenter Prospective Interventional Study to Evaluate the Frequency of FCGR3A Gene Polymorphisms in Patients With Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody Disease, and Multiple Sclerosis.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Evaluation ofFrontiers in medicine · 2026Pooled it
- Comprehensive Assessment of the Association between FCGRs polymorphisms and the risk of systemic lupus erythematosus: Evidence from a Meta-Analysis.Scientific reports · 2016Pooled it
- Lack of association of FcγRIIIb polymorphisms with systemic lupus erythematosus: a meta-analysis.Rheumatology international · 2011Pooled it
- Meta analysis on the association between FcgammaRIIa-R/H131 polymorphisms and systemic lupus erythematosus.Molecular biology reports · 2009Pooled it
- Site-Specific Glycosylation Analysis of Human and Murine Fcγ Receptor II Family Members Reveals Variant-SpecificJournal of proteome research · 2024Article
- Evaluation of intra- and inter-individual variations in plasma belimumab concentrations in adult patients with systemic lupus erythematosus.Pharmacology research & perspectives · 2024Article
- Impacts of FcγRIIB and FcγRIIIA gene polymorphisms on systemic lupus erythematous disease activity index.BMC research notes · 2021Article
- Steroid hormone-related polymorphisms associate with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium.Scientific reports · 2019Article
- Association of FcγRIIB and FcγRIIA R131H gene polymorphisms with renal involvement in Egyptian systemic lupus erythematosus patients.Molecular biology reports · 2014Article
- Human FcR polymorphism and disease.Current topics in microbiology and immunology · 2014Review
- Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- FCGR3A V(176) polymorphism for systemic lupus erythematosus susceptibility in Mexican population.Rheumatology international · 2011Article
- Fc γ RIIA Genotypes and Its Association with Anti-C1q Autoantibodies in Lupus Nephritis (LN) Patients from Western India.Autoimmune diseases · 2010Article
- Fc gamma receptor polymorphisms in systemic lupus erythematosus and their correlation with the clinical severity of the disease.Indian journal of human genetics · 2008Article
- Fcepsilon- and Fcgamma-receptor signaling in diseases.Springer seminars in immunopathology · 2006Review
- Activating and inhibitory FcgammaRs in autoimmune disorders.Springer seminars in immunopathology · 2006Review
- Unraveling the genetics of systemic lupus erythematosus.Springer seminars in immunopathology · 2006Review
- Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE.The Journal of experimental medicine · 2006Article
- Clinical and genetic risk factors of herpes zoster in patients with systemic lupus erythematosus.Rheumatology international · 2005Article
- Association of the oestrogen receptor alpha gene polymorphisms with disease onset in systemic lupus erythematosus.Annals of the rheumatic diseases · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReceptors for IgG play an important part in immune complex clearance. Several studies have identified polymorphisms of receptors for the Fc fragment of IgG (FcgammaR) as genetic factors influencing susceptibility to disease or disease course of systemic lupus erythematosus (SLE).
objectiveTo examine these possibilities by evaluating a panel of clinical parameters in a cohort of 140 German patients with SLE for correlations with the FcgammaRIIa, IIIa, and IIIb polymorphisms in an explorative study.
methods140 German patients with SLE according to American College of Rheumatology (ACR) criteria and 187 German controls were genotyped for the FcgammaRIIa, IIIa, and IIIb polymorphisms. Associations between FcgammaR genotypes, combined genotypes and clinical as well as laboratory features were analysed.
resultsNo significant skewing of any of the three FcgammaR polymorphisms was seen in the German SLE cohort studied. Various clinical and serological parameters were found more frequently and at younger age in homozygous patients with the genotypes IIA-R/R131 or IIIA-F/F158 than in patients with IIA-H/H131 or IIIA-V/V158. These effects were even more pronounced in patients with the low binding combined phenotypes of the FcgammaRIIa, IIIa (double negative phenotypes) and FcgammaRIIa, IIIa, and IIIb (triple negative phenotypes). In patients with the double negative IIA and IIIA genotypes significantly higher frequencies of nephritis (63% v 33%) and proteinuria according to ACR criteria (58% v 11%), anaemia (84% v 55%), and anticardiolipin antibodies (63% v 22%) were found than in patients with the double positive genotypes. Patients with the IIA-R/R131 genotype and the double negative homozygous genotype had an earlier incidence of clinical symptoms, haematological and immunological abnormalities. Accordingly, SLE is diagnosed earlier in these patients, the difference reaching statistical significance only in the double negative v the double positive genotype (26.3 v 39.5 years) and the IIIA-F/F158 genotype v the rest (26.7 v 32.0 years). Most relevant is the fact that a higher median disease activity (ECLAM score) was demonstrated, both in the IIA-R/R131 homozygous (3.3 v 2.7) and the double negative (3.4 v 2.3) patients, reaching statistical significance in the first group.
conclusionThe results of this explorative study support the view that the FcgammaRIIa/IIIa and IIIb polymorphisms constitute factors influencing clinical manifestations and the disease course of SLE but do not represent genetic risk factors for the occurrence of SLE. Higher frequencies of clinical symptoms, haematological and immunological abnormalities as well as an earlier onset of clinical symptoms, haematological and immunological markers of active disease were found in patients with the IIA-R/R131 genotype and the double negative and triple negative genotypes.
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