ArticleWorld journal of gastroenterology2002
Loss of heterozygosity on long arm of chromosome 22 in sporadic colorectal carcinoma.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
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- Hexavalent Chromium-Induced Chromosome Instability Drives Permanent and Heritable Numerical and Structural Changes and a DNA Repair-Deficient Phenotype.Cancer research · 2018Article
- Loss of NF2/Merlin expression in advanced sporadic colorectal cancer.Cellular oncology (Dordrecht, Netherlands) · 2014Article
- MicroRNAs in pancreatic ductal adenocarcinoma.World journal of gastroenterology · 2011Article
- 22q13.32 deletion and duplication and inversion in the same family: a rare occurrence.ISRN pediatrics · 2011Article
- Survival after colorectal cancer diagnosis is associated with colorectal cancer family history.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2008Article
- Refined mapping of loss of heterozygosity on 1q31.1-32.1 in sporadic colorectal carcinoma.World journal of gastroenterology · 2008Article
- Amplification of D22S283 as a favorable prognostic indicator in liver fluke related cholangiocarcinoma.World journal of gastroenterology · 2006Article
- Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers.Oncogene · 2005Article
- Detailed deletion mapping of loss of heterozygosity on 22q13 in sporadic colorectal cancer.World journal of gastroenterology · 2005Article
- Loss of heterozygosity on chromosome 1 in sporadic colorectal carcinoma.World journal of gastroenterology · 2004Article
- No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer.Breast cancer research : BCR · 2004Article
- Comparative evaluation of immune response after laparoscopical and open total mesorectal excisions with anal sphincter preservation in patients with rectal cancer.World journal of gastroenterology · 2003Article
- Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer.World journal of gastroenterology · 2003Article
- Refinement of heterozygosity loss on chromosome 5p15 in sporadic colorectal cancer.World journal of gastroenterology · 2003Article
- Angiography for diagnosis and treatment of colorectal cancer.World journal of gastroenterology · 2003Article
- Genome-wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer.International journal of gastrointestinal cancer · 2003Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe loss of heterozygosity (LOH) on tumor suppressor genes is believed to play a key role in carcinogenesis of colorectal cancer. In this study, we analyzed the LOH at 5 loci on the long arm of chromosome 22 in sporadic colorectal cancer to identify additional loci involved in colorectal tumorigenesis.
methodsFive polymorphic microsatellite markers were analyzed in 83 cases of colorectal and normal DNA by PCR. PCR products were eletrophoresed on an ABI 377 DNA sequencer; Genescan 3.1 and Genotype 2.1 software were used for LOH scanning and analysis. Comparison between LOH frequency and clinicopathological data were performed by chi(2) test. P<0.05 was considered as statistically significant.
resultsThe average LOH frequency on chromosome 22q was 28.38 %. The region between markers D22S280 and D22S274 (22q12.2-q13.33) exhibited relatively high LOH frequency. The two highest LOH loci with frequencies of 35.09 % and 34.04 % was identified on D22S280 (22q12.2-12.3) and D22S274 (22q13.32-13.33). 8 cases showed LOH at all informative loci, suggesting that one chromosome 22q had been completely lost. On D22S274 locus, LOH frequency of rectal cancer was 50 % (9/18), which was higher than that of proximal colon cancer (12 %, 2/17) (P=0.018). The frequency of distal colon cancer was 42 % (5/12), also higher than that of proximal colon cancer. But there was no statistical significance. Putting both the tumors in distal colon and rectum together into consideration, the frequency, 47 % (14/30), was higher than that of proximal colon cancer (P=0.015),suggesting the mechanism of carcinogenisis was different in both groups.
conclusionsThis study provided evidence for the involvement of putative tumor suppressor genes related to the sporadic colorectal carcinoma on chromosome 22q. The tumor-suppressor-gene(s) might locate on the 22q12.2-12.3 and/or 22q13.32-13.33.
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