ArticleWorld journal of gastroenterology2002
Arterial chemotherapy of 5-fluorouracil and mitomycin C in the treatment of liver metastases of colorectal cancer.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Selective intra-arterial mitomycin-C infusions for treatment-refractory colorectal liver metastases.Journal of gastrointestinal oncology · 2025Article
- Hepatic artery pseudoaneurysm-the Mayo Clinic experience and literature review.Frontiers in medicine · 2024Article
- Recurrent hepatic artery pseudoaneurysm repair with overlapping tapered stent-graft technique.Radiology case reports · 2023Article
- Intra-arterial hepatic chemotherapy for unresectable colorectal liver metastases: a review of medical devices complications in 3172 patients.Medical devices (Auckland, N.Z.) · 2009Article
- Hemorrhage associated with hepatic artery pseudoaneurysms after regional chemotherapy with floxuridine: case report.International seminars in surgical oncology : ISSO · 2008Article
- Comparative evaluation of immune response after laparoscopical and open total mesorectal excisions with anal sphincter preservation in patients with rectal cancer.World journal of gastroenterology · 2003Article
- Prognostic factors in 165 elderly colorectal cancer patients.World journal of gastroenterology · 2003Article
- Toxicities and therapeutic effect of 5-fluorouracil controlled release implant on tumor-bearing rats.World journal of gastroenterology · 2003Article
- Angiography for diagnosis and treatment of colorectal cancer.World journal of gastroenterology · 2003Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimRegional chemotherapy using hepatic artery catheters is a good method of treating patients with colorectal cancer liver metastases. We investigated the survival of patients with liver metastases from colorectal cancer using 5-fluorouracil (5-FU) and mitomycin C Cthrough implantable hepatic arterial infusion port.
methodsSeventy-five patients with inoperable liver metastases from colorectal cancer were included between March, 1992 and November, 2001. We placed implantable hepatic arterial catheter (HAC) port by laparotomy. 5-FU, 1 000 mg/ m(2)/d continuous infusion for five days every four weeks, was delivered in the hepatic arterial catheter through the port. Mitomycin C, 30 mg/m(2)/d infusion in the first day every cycle through the port. Response to the treatment was evaluated by serial determinations of plasma CEA and imaging techniques consisting of computerized tomography and sonography of liver.
resultsSixty-eight were performed hepatic artery chemotherapy and fifty-six were followed up among seventy-five HAC patients. Twenty-six patients(46.4 %) have responded and 4 complete remission were achieved. Eight patients (14.3 %) had stable liver metastases. Twenty-two patients (39.3 %) were progressed with increased tumor size and number. Twenty-nine patients(51.8%) had a decreased serum CEA level, while 10 patients (17.9 %) were stable and 17 patients (30.4 %) had an increased serum CEA level. There were no operative death in this series. Complications, which occurred in 18 patients (32.1 %), were as followed: hepatic artery thrombosis in 11, Upper gastric and intestinal bleeding in 3, liver abscess in 1, pocket infection in 1, cholangitis in 1, and hepatic artery pseudo-aneurysm in one patient.
conclusionCombined infusion of 5-FU and mitomycin C by hepatic artery catheter port is an effective treatment for liver metastases from colorectal cancer. The high response and lower complication rates prove the adjuvant treatment of colorectal cancer with this treatment.
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