ArticleWorld journal of gastroenterology2002
Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance.
Article in World journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis.PloS one · 2016Pooled it
- Evidence That β1-Integrin Is Required for the Anti-Viability and Anti-Proliferative Effect of Resveratrol in CRC Cells.International journal of molecular sciences · 2022Article
- Functional and clinical characteristics of focal adhesion kinases in cancer progression.Frontiers in cell and developmental biology · 2022Review
- Mechano-signalling, induced by fullerene CInternational journal of nanomedicine · 2019Article
- The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists.Molecular carcinogenesis · 2017Article
- Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity.Oncotarget · 2016Article
- Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.Molecular pharmacology · 2016Article
- Research of shRNAmir inhibitory effects towards focal adhesion kinase expression in the treatment of gastric cancer.Oncology letters · 2015Article
- Biomarkers for predicting future metastasis of human gastrointestinal tumors.Cellular and molecular life sciences : CMLS · 2013Review
- FAK, CD44v6, c-Met and EGFR in colorectal cancer parameters: tumour progression, metastasis, patient survival and receptor crosstalk.International journal of colorectal disease · 2013Article
- Inhibition of focal adhesion kinase induces apoptosis in human gastric carcinoma cells (SGC-7901).Molecular biology reports · 2013Article
- In oral squamous cell carcinoma, high FAK expression is correlated with low P53 expression.Virchows Archiv : an international journal of pathology · 2012Article
- Focal adhesion kinases in adhesion structures and disease.Journal of signal transduction · 2012Article
- Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis.Molecular cancer · 2011Article
- Expression and clinical significance of FAK and Src proteins in human endometrial adenocarcinoma.Pathology oncology research : POR · 2011Article
- Phosphorylation of focal adhesion kinase at Tyr397 in gastric carcinomas and its clinical significance.The American journal of pathology · 2010Article
- Progress in researches about focal adhesion kinase in gastrointestinal tract.World journal of gastroenterology · 2009Review
- Application of a novel method of double APAAP staining with subsequent quantitative image analysis to the examination of integrin expression in undifferentiated-type gastric carcinomas.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Expression and clinical significance of focal adhesion kinase in the two distinct histological types, intestinal and diffuse, of human gastric adenocarcinoma.Pathology oncology research : POR · 2009Article
- Clinical significance of focal adhesion kinase in resectable pancreatic cancer.World journal of surgery · 2006Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo detect the expression pattern of FAK (focal adhesion kinase) and integrin alpha5 and beta1 subunits in different kinds of cancerous tissues and to study their correlation with clinicopathological data including tumor type, grade and lymph node status.
methodsUsing an immunohistochemical technique, we examined the expression of FAK and integrin and subunits in cancerous and noncancerous tissues obtained from 75 patients with gastric carcinomas, 21 colorectal carcinomas, 16 hepatocellular carcinomas, 20 uterocervical carcinomas, and 20 breast carcinomas.
resultsThe staining of FAK was stronger in cancerous than in noncancerous areas. Enhanced expression of FAKwas detected in poor-differentiated carcinoma of the stomach and colorectum. Tumors with lymph node metastases had more FAK protein than those without metastases. In addition, the deeper the extent of tumor infiltration, the higher the FAK expression. The expression of integrin alpha5 and beta1 subunits was lower in cancerous areas than in noncancerous areas, but it was higher in well-differentiated cancerous tissues than in poor differentiated tissues. The relationship between the expression of integrin alpha5 and beta1 subunits and infiltration or metastasis was not significant. Cancerous tissues with stronger FAK expression (++ or +++) also had a higher expression of integrin alpha5 and beta1 subunits in the tumor and its unaffected margins.
conclusionFAK is a better marker for carcinogenesis and the progression of cancer than integrin alpha5 and beta1 subunit, and it may be not only a transformation-linked enzyme but also a progression-linked enzyme.
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