ReviewGene expression2002
ZAS: C2H2 zinc finger proteins involved in growth and development.
Review in Gene expression, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- An ancestral molecular response to nanomaterial particulates.Nature nanotechnology · 2023Pooled it
- Exploring the potential function of trace elements in human health: a therapeutic perspective.Molecular and cellular biochemistry · 2023Review
- HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis.Frontiers in immunology · 2021Article
- Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells.Nature communications · 2020Article
- CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures.Journal of cellular and molecular medicine · 2020Article
- Molecular and Physio-Biochemical Characterization of Cotton Species for Assessing Drought Stress Tolerance.International journal of molecular sciences · 2018Article
- Mutations in HIVEP2 are associated with developmental delay, intellectual disability, and dysmorphic features.Neurogenetics · 2016Article
- Loss-of-function variants in HIVEP2 are a cause of intellectual disability.European journal of human genetics : EJHG · 2016Article
- Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation.The Journal of biological chemistry · 2014Article
- Immune-related functions of the Hivep gene family in East African cichlid fishes.G3 (Bethesda, Md.) · 2013Article
- Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.The Journal of clinical investigation · 2013Article
- Article
- Control of bone resorption in mice by Schnurri-3.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- ZAS3 accentuates transforming growth factor β signaling in epithelial cells.Cellular signalling · 2011Article
- MicroRNA-181a modulates gene expression of zinc finger family members by directly targeting their coding regions.Nucleic acids research · 2010Article
- Alternative trans-splicing of Caenorhabditis elegans sma-9/schnurri generates a short transcript that provides tissue-specific function in BMP signaling.BMC molecular biology · 2010Article
- NF-kappaB regulation: the nuclear response.Journal of cellular and molecular medicine · 2009Review
- Green transcription factors: a chlamydomonas overview.Genetics · 2008Article
- Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development.Gene expression · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A ZAS gene encodes a large protein with two separate C2H2 zinc finger pairs that independently bind to specific DNA sequences, including the kappaB motif. Three paralogous mammalian genes, ZAS1, ZAS2, and ZAS3, and a related Drosophila gene, Schnurri, have been cloned and characterized. The ZAS genes encode transcriptional proteins that activate or repress the transcription of a variety of genes involved in growth, development, and metastasis. In addition, ZAS3 associates with a TNF receptor-associated factor to inhibit NF-kappaB- and JNK/ SAPK-mediated signaling of TNF-alpha. Genetic experiments show that ZAS3 deficiency leads to proliferation of cells and tumor formation in mice. The data suggest that ZAS3 is important in controlling cell growth, apoptosis, and inflammation. The potent vasoactive hormone endothelin and transcription factor AP2 gene families also each consist of three members. The ZAS, endothelin, and transcription factor AP2 genes form several linkage groups. Knowledge of the chromosomal locations of these genes provides valuable clues to the evolution of the vertebrate genome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.