ArticleOncogene2002
Differentially expressed genes associated with mouse lung tumor progression.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- IGFBP-6 Network in Chronic Inflammatory Airway Diseases and Lung Tumor Progression.International journal of molecular sciences · 2023Review
- Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review.Frontiers in oncology · 2021Review
- Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer.Oncology reports · 2019Article
- Could cell division cycle protein 42 be a target for lung cancer treatment?Translational cancer research · 2019Review
- Total alkaloids ofOncology letters · 2018Article
- Proteins regulating the intercellular transfer and function of P-glycoprotein in multidrug-resistant cancer.Ecancermedicalscience · 2017Review
- An 8-gene signature for prediction of prognosis and chemoresponse in non-small cell lung cancer.Oncotarget · 2016Article
- Recent insights into the actions of IGFBP-6.Journal of cell communication and signaling · 2015Article
- FasL -844T/C and Fas -1377G/A: mutations of pulmonary adenocarcinoma in South China and their clinical significances.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- The clinical and biological significance of STAT1 in esophageal squamous cell carcinoma.BMC cancer · 2014Article
- Article
- Zoledronic acid sensitizes renal cell carcinoma cells to radiation by downregulating STAT1.PloS one · 2013Article
- Novel functions for Rab GTPases in multiple aspects of tumour progression.Biochemical Society transactions · 2012Review
- Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours.European journal of cancer (Oxford, England : 1990) · 2012Article
- RAS Mutations and Oncogenesis: Not all RAS Mutations are Created Equally.Frontiers in genetics · 2011Article
- Gene expression-based classification of non-small cell lung carcinomas and survival prediction.PloS one · 2010Article
- Strain-dependent differences in susceptibility to lung cancer in inbred mice exposed to mainstream cigarette smoke.Cancer letters · 2009Article
- Article
- Gene expression profiling of chemically induced rat bladder tumors.Neoplasia (New York, N.Y.) · 2007Article
- Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions.Oncogene · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
To detect altered gene expression associated with mouse lung tumor progression, we compared the gene expression profile of lung adenocarcinomas with that of lung adenomas and normal lungs. Autoradiographic analysis showed that among the 588 genes surveyed, 152 genes were detected and the remaining 436 genes did not give any signals. A gene-specific semiquantitative reverse transcription polymerase chain reaction method was used to confirm the expression profile. A total of 29 genes was found to be differentially expressed in mouse lung tumors when compared to normal lungs. The pattern of expression, either underexpression or overexpression, was the same for 10 genes between adenocarcinomas and adenomas. Among them, seven genes were overexpressed, two genes were underexpressed and one gene was lost. Interestingly, 19 genes showed differential expression or increased incidence or difference in level of change between lung adenomas and adenocarcinomas, including Stat1, ADAP, IGFBP-6, PDGF-A, TGF-beta2, Int-3, VEGFR2, BAX, BAG-1, c-Jun, FasL, TRAIL, YB-1, CD31, Cdc42, B-raf, Rab-2, Abi-1, and ACE. These genes can be designated as candidate 'lung tumor progression' (LTP) genes because their expression changes may specifically affect lung tumor progression in mice. Further analyses of these candidate LTP genes may provide new leads for elucidation of lung tumor progression in mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.