ArticleThe Plant cell2002
Arabidopsis transcriptome profiling indicates that multiple regulatory pathways are activated during cold acclimation in addition to the CBF cold response pathway.
Article in The Plant cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 579 papers, 1 of them a synthesis that pooled it.
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Who cites it
579 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,595 citations in OpenAlex.
- Pooled it
- Interaction between cold and high light stresses distinguishes transcriptional responses for freezing tolerance and photoprotection inPlant signaling & behavior · 2026Article
- Ectopic expression of a Penicillium oxalicum cyclophilin gene in Arabidopsis thaliana imparts tolerance to cold stress.Transgenic research · 2026Article
- Crops exposed to extreme conditions: perspectives of gene editing to improve stress tolerance.Plant cell reports · 2026Review
- Vernalization-responsive intronless genes in faba bean and the development of KASP markers.Plant cell reports · 2026Article
- Allelic variation at a single locus distinguishes spring and winter faba beans.Nature genetics · 2026Article
- Cloning, Expression and Functional Study ofPlants (Basel, Switzerland) · 2026Article
- Unravelling the molecular mechanisms of vegetative-to-reproductive transition in Cynara cardunculus by RNA-Seq analysis.Plant molecular biology · 2026Article
- Deciphering the ceRNA Network in Alfalfa: Insights into Cold Stress Tolerance Mechanisms.Biomolecules · 2026Article
- Memory in the wall: expanding our understanding of the roles of plant cell walls.The New phytologist · 2026Review
- Article
- Predicting Gene Expression Responses to Cold inGenes · 2025Article
- The blue light receptor ZmFKF1a recruits ZmGI1 to the nucleus to accelerate shoot apex development and flowering in maize.The Plant cell · 2025Article
- A timeline of discovery and innovation in Arabidopsis.The Plant cell · 2025Article
- Upregulated expression of MYB4, DREB1 and AP37 transcription factors modulates cold stress response in high-altitude Himalayan rice via time-dependent ROS regulation.Molecular biology reports · 2025Article
- Article
- Remodelled ribosomal populations synthesize a specific proteome in proliferating plant tissue during cold.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Functional Characterization of Pomegranate CAMTA3 in Cold Stress Responses.Plants (Basel, Switzerland) · 2025Article
- Identifications of Genes Involved in ABA and MAPK Signaling Pathways Positively Regulating Cold Tolerance in Rice.Plants (Basel, Switzerland) · 2025Article
- Plant Coping with Cold Stress: Molecular and Physiological Adaptive Mechanisms with Future Perspectives.Cells · 2025Review
519 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many plants, including Arabidopsis, increase in freezing tolerance in response to low, nonfreezing temperatures, a phenomenon known as cold acclimation. Previous studies established that cold acclimation involves rapid expression of the CBF transcriptional activators (also known as DREB1 proteins) in response to low temperature followed by induction of the CBF regulon (CBF-targeted genes), which contributes to an increase in freezing tolerance. Here, we present the results of transcriptome-profiling experiments indicating the existence of multiple low-temperature regulatory pathways in addition to the CBF cold response pathway. The transcript levels of approximately 8000 genes were determined at multiple times after plants were transferred from warm to cold temperature and in warm-grown plants that constitutively expressed CBF1, CBF2, or CBF3. A total of 306 genes were identified as being cold responsive, with transcripts for 218 genes increasing and those for 88 genes decreasing threefold or more at one or more time points during the 7-day experiment. These results indicate that extensive downregulation of gene expression occurs during cold acclimation. Of the cold-responsive genes, 48 encode known or putative transcription factors. Two of these, RAP2.1 and RAP2.6, were activated by CBF expression and thus presumably control subregulons of the CBF regulon. Transcriptome comparisons indicated that only 12% of the cold-responsive genes are certain members of the CBF regulon. Moreover, at least 28% of the cold-responsive genes were not regulated by the CBF transcription factors, including 15 encoding known or putative transcription factors, indicating that these cold-responsive genes are members of different low-temperature regulons. Significantly, CBF expression at warm temperatures repressed the expression of eight genes that also were downregulated by low temperature, indicating that in addition to gene induction, gene repression is likely to play an integral role in cold acclimation.
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